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DISODIUM ACETYL GLUCOSAMINE PHOSPHATE.

Valuable CAS 102029-88-9 / SKIN CONDITIONING

Disodium Acetyl Glucosamine Phosphate is a biotechnologically derived N-acetyl-glucosamine (NAG) derivative that significantly enhances skin's natural hydration and elasticity. It supports a more even skin tone by reducing discoloration and promotes overall skin regeneration.

Summary

Skin Conditioning Hydration Booster Anti-Aging Brightening Agent Gentle Exfoliant Antioxidant Anti-Inflammatory Photoprotective Elasticity Enhancer Firming Agent

Science

Mechanism of Action

This ingredient functions as a vital precursor, empowering skin cells to synthesize hyaluronic acid (HA) and other glycosaminoglycans (GAGs). By providing the necessary energy for HA production, it significantly boosts skin hydration, firmness, and elasticity. It also strengthens the dermal-epidermal junction (DEJ), improving cell cohesion and communication, which in turn stimulates cellular regeneration and tissue recovery. Furthermore, it exhibits antioxidant, anti-inflammatory, and photoprotective properties. Similar to its precursor, it contributes to gentle exfoliation by loosening dead skin cell bonds and inhibits tyrosinase activity, effectively reducing melanin production and hyperpigmentation for a brighter, more uniform complexion.

Research

Clinical Evidence

High confidence
Effective range 0.4–6%
Optimal

2%

Key findings

  1. 01 Effective in reducing visible discolorations, particularly when paired with niacinamide (studies on Acetyl Glucosamine).
  2. 02 Significant reduction in facial spots and pigmentation when applied twice daily for 8 weeks (study on Acetyl Glucosamine in a facial lotion).
  3. 03 Manufacturer's in-vitro and ex-vivo tests showed NovHyal (a synonym) can boost GAGs production by 84% in 10 days and increase hyaluronic acid synthesis by 282% in 2 days.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.4%
Red flag below
0.4%

With documented general usage levels starting at 0.4% and observed clinical efficacy at 2-5%, Disodium Acetyl Glucosamine Phosphate is typically utilized at concentrations that are functionally active, indicating it is not commonly 'dusted' in formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 7.5
0 7 14

Stability

Optimal stability is observed within a pH range of 6.0 to 7.5, a characteristic extrapolated from its precursor, Acetyl Glucosamine.

Synergies

  • Niacinamide

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The Expert Panel for Cosmetic Ingredient Safety (CIR) deemed glucosamine ingredients, including Acetyl Glucosamine, safe for cosmetic use within current practices and concentrations, provided formulations are non-irritating. The ingredient, and its relatives, show low concerns for cancer, allergies, and reproductive toxicity according to EWG's Skin Deep database.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Disodium Acetyl Glucosamine Phosphate is a valuable ingredient for comprehensive skin health, offering significant hydration, brightening, and anti-aging benefits with excellent tolerability.

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