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DIPROPYLENE GLYCOL SALICYLATE.

Valuable CAS 68683-31-8 / 55940-73-3 / 7491-14-7 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING, TONIC, VISCOSITY CONTROLLING

Dipropylene Glycol Salicylate is a unique glycol salicylate designed for effective skin penetration, acting as a non-steroidal anti-inflammatory agent. It addresses inflammation and discomfort by modulating key pain and inflammatory pathways at a cellular level. Additionally, this ingredient contributes to formulations as a skin conditioning agent and emollient, enhancing overall product performance.

Summary

Anti-inflammatory Analgesic Skin Conditioning Emollient Surfactant - Cleansing Tonic Viscosity Controlling

Science

Mechanism of Action

Upon topical application, Dipropylene Glycol Salicylate readily penetrates the skin, initiating its anti-inflammatory action. It functions as a non-steroidal anti-inflammatory drug (NSAID) through the inhibition of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This enzymatic suppression significantly reduces the synthesis of prostaglandins, thereby alleviating inflammation and associated pain. Further anti-inflammatory effects are achieved by modulating the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The Dipropylene Glycol base confers excellent stability, being a non-reactive, low-odor solvent. It demonstrates enhanced resistance to oxidation compared to propylene glycol and maintains high-temperature stability. Its significant miscibility with water, alcohols, and numerous aromatic oils further contributes to robust overall formulation stability.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that the Dipropylene Glycol base is safe for use in cosmetic formulations when designed to be non-irritating. Similarly, Salicylic Acid and 17 related salicylates have been deemed safe in cosmetics under current use practices and concentrations, provided they are formulated to be non-irritating and non-sensitizing. This ingredient shows a low hazard profile, as 99.8% of reported cases do not meet GHS hazard criteria. The Environmental Working Group (EWG) rates it 'LOW' for potential concerns including cancer, allergies & immunotoxicity, developmental & reproductive toxicity, and use restrictions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Dipropylene Glycol Salicylate is a valuable multi-functional ingredient, offering significant anti-inflammatory and pain-relieving benefits with a favorable safety and skin compatibility profile across all skin types.

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