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DIPROPYLENE GLYCOL DIMETHYL ETHER.

Valuable CAS 111109-77-4 / SOLVENT

Dipropylene Glycol Dimethyl Ether is a versatile glycol ether that primarily functions as a solvent and a chemical permeation enhancer in skincare formulations. It enhances the absorption of active ingredients by transiently modifying the stratum corneum, while also contributing to product stability and providing emollient properties.

Summary

Solvent Permeation Enhancer Emollient Product Stabilizer Coupling Agent

Science

Mechanism of Action

Its primary mechanism involves transiently modifying the intercellular lipid structure within the stratum corneum, the skin's outermost barrier, thereby facilitating enhanced penetration of other active ingredients. Beyond permeation enhancement, it effectively dissolves various cosmetic components and imparts emollient characteristics to formulations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 1 – 14
0 7 14

Stability

Dipropylene Glycol Dimethyl Ether exhibits exceptional chemical stability across a broad pH range, from 1 to 14, making it highly versatile for diverse cosmetic formulations, including those with strong acidic or alkaline components. As an aprotic solvent, it is particularly suitable for proton-sensitive systems. It is hygroscopic and can absorb moisture from the air; like other glycol ethers, it may form peroxides in the presence of oxygen and is often stabilized with antioxidants such as BHT.

Conflicts

  • strong oxidizing agents
  • aluminium (glycol ethers can corrode scratched aluminium surfaces, potentially releasing hydrogen gas)
  • strong bases at elevated temperatures (risk of runaway reactions)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While no direct Cosmetic Ingredient Review (CIR) or SCCS assessments were found for Dipropylene Glycol Dimethyl Ether, structurally similar compounds like Dipropylene Glycol Monomethyl Ether (DPGME) have been assessed by the US EPA, noting low acute toxicity via oral, dermal, and inhalation routes, and described as not a skin irritant and only slightly irritating to the eye in rabbits. Dipropylene Glycol (DPG) is also considered generally safe. Safety Data Sheets indicate that Dipropylene Glycol Dimethyl Ether itself has low toxicity, is not classified as a PBT (persistent, bioaccumulative, toxic) or vPvB, and does not contain endocrine disruptors at concentrations of ≥0.1%. It is subject to reporting for significant new uses under 40 CFR 721.3550.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dipropylene Glycol Dimethyl Ether is a valuable formulation component that enhances active ingredient delivery and product stability, exhibiting a favorable safety profile based on available data and related compounds.

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