Science
Mechanism of Action
At a molecular level, Dipotassium Glycyrrhizate intervenes in key inflammatory pathways by inhibiting mediators such as prostaglandins and histamine, thereby dampening signals that lead to redness and discomfort. It specifically blocks nuclear factor-kappa B (NF-κB) signaling, a crucial regulator of inflammation-causing genes, and reduces the activity of phospholipase A2 and cyclooxygenase. Furthermore, it helps regulate sebum production to prevent clogged pores and can inhibit tyrosinase, an enzyme central to melanin synthesis, which assists in diminishing dark spots. Its action extends to preserving skin's hyaluronic acid and moderating cortisol breakdown, further contributing to its calming effect.
Research
Clinical Evidence
High confidence0.2%
Key findings
- 01 Lightened hyperpigmentation by up to 20% over 12 weeks.
- 02 Reduced inflammation, promoted granulation tissue, and supported re-epithelialization in skin wound healing over 14 days.
- 03 Demonstrated effectiveness for anti-irritancy in finished products.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal pH for stability generally ranges between 4.0 and 8.0. It requires storage in a dark and dry environment at 10°C to 25°C, with temperatures above 60°C to be avoided. Its hygroscopic nature and mild electrolyte properties may contribute to a slight liquefaction in some formulations.
Conflicts
- oxidizing agents
Safety
Safety Profile
The independent Cosmetic Ingredient Review (CIR) Expert Panel has determined Dipotassium Glycyrrhizate to be safe for cosmetic use. It is widely considered non-irritating and non-sensitizing, and generally well-tolerated across all skin types. However, the Australian Industrial Chemicals Introduction Scheme (AICIS) recommends its use in dermal cosmetic products at concentrations no more than 0.2% and advises against its inclusion in topical products intended for the eye. The ingredient is also noted to be poorly absorbed through the skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Dipotassium Glycyrrhizate is a highly valuable ingredient for its broad-spectrum benefits, including significant anti-inflammatory, soothing, and skin-brightening properties, making it an excellent choice for diverse skincare formulations.
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References
Sources