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Moumoujus

DIPHYLLEIA GRAYI CALLUS EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING

Diphylleia Grayi Callus Extract is a plant-derived ingredient notable for its multi-functional benefits, primarily its robust antioxidant capabilities. It effectively reduces cellular oxidative stress and demonstrates potential for skin brightening, wrinkle reduction, and overall skin and hair conditioning.

Summary

Antioxidant Skin Conditioning Antimicrobial Astringent Hair Conditioning Anti-aging Skin Brightening Anti-wrinkle

Science

Mechanism of Action

This extract acts as a potent antioxidant by effectively neutralizing DPPH and ABTS radicals and significantly reducing intracellular reactive oxygen species (ROS), thereby mitigating oxidative stress that contributes to skin aging. Its mechanism also extends to inhibiting tyrosinase and L-DOPA oxidation for potential skin brightening, and collagenase inhibition for anti-wrinkle effects. Furthermore, it possesses antimicrobial, astringent, and conditioning properties for both dermal and hair applications.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

1%

Key findings

  1. 01 At a 1% concentration, the extract exhibited significant antioxidant activity, demonstrating 84.21% DPPH radical scavenging and 88.21% ABTS radical scavenging. It effectively reduced oxidative stress (intracellular ROS) in human normal skin cells without compromising cell viability. The half-maximal inhibitory concentration (IC50) for DPPH and ABTS scavenging was 3.23±0.13 mg/mL and 3.42±0.35 mg/mL, respectively.

Transparency

Dusting Analysis

Not commonly dusted

Efficacy for antioxidant activity and reduction of oxidative stress has been demonstrated at a concentration of 1%, which is a clinically relevant percentage. There is no indication from the provided data that this ingredient is commonly used at sub-efficacious concentrations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Activity has been observed at a pH of 6.5, as indicated by its successful use in a tyrosinase inhibition assay at this pH.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

No cytotoxicity was observed on normal human skin cells at a concentration of 1% (10 mg/mL). While generally considered non-irritating, some sources note a potential for irritation, especially when combined with other challenging ingredients, which could manifest as inflammation or dryness.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Diphylleia Grayi Callus Extract is a valuable, multi-functional ingredient demonstrating significant antioxidant efficacy at 1%, offering notable potential for anti-aging, skin brightening, and conditioning benefits.

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