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Moumoujus

DIPEPTIDE-51.

Valuable / NOT REPORTED

DIPEPTIDE-51 is a bio-active peptide that signals the skin to activate its inherent repair and renewal mechanisms. It effectively addresses hyperpigmentation by enhancing cellular waste breakdown and contributes to cellular longevity, leading to a more youthful and radiant complexion.

Summary

skin conditioning anti-aging brightening pigmentation reduction skin renewal wrinkle reduction skin firming

Science

Mechanism of Action

DIPEPTIDE-51, specifically as Pentasodium Tetracarboxymethyl Dipeptide-51, functions by activating the skin's endogenous repair pathways. It robustly stimulates autophagy, a critical cellular process for degrading and recycling cellular components, which effectively breaks down melanosomes within keratinocytes and concurrently inhibits their uptake, directly mitigating skin pigmentation. This peptide further induces cellular reprogramming in the basal layer of the epidermis, extending its self-renewal capacity, which results in a reduction of aging signs and enhanced skin radiance. Additionally, it promotes a gradual regeneration of mature skin, strengthens its structural integrity, and visibly diminishes the appearance of wrinkles.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

2%

Key findings

  1. 01 A clinical study demonstrated that a formulation containing 2% DIPEPTIDE-51 effectively stimulated autophagy, leading to the breakdown of melanosomes in keratinocytes and inhibiting melanosome uptake, alongside promoting cellular reprogramming for enhanced self-renewal, targeting both anti-hyperpigmentation and anti-aging benefits.

Transparency

Dusting Analysis

Not commonly dusted

No data available to indicate common dusting practices or specific thresholds for DIPEPTIDE-51.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The 'Pentasodium Tetracarboxymethyl' component suggests a water-soluble salt form. While specific optimal pH ranges for DIPEPTIDE-51 are not detailed in the available research, peptides generally exhibit pH-dependent solubility and stability. Certain dipeptides may show some oil solubility based on their hydrophobicity and pH, with zwitterionic compounds often more oil-soluble at neutral pH.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Comprehensive safety assessments, including reviews by CIR, SCCS, or FDA, specifically for DIPEPTIDE-51 or its derivative Pentasodium Tetracarboxymethyl Dipeptide-51, are currently unavailable in the provided research data. Therefore, specific potential maximum concentrations and sensitization risks remain undetermined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

DIPEPTIDE-51 is a valuable active ingredient for comprehensive skin rejuvenation and brightening, although further comprehensive safety data would provide a more complete profile.

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