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DIPEPTIDE-5.

Valuable CAS - / SKIN CONDITIONING

DIPEPTIDE-5, primarily researched in its Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine derivative form, is a sophisticated synthetic signal peptide. It is engineered to bolster the skin's dermal architecture, visibly enhancing firmness, smoothness, and overall youthful appearance.

Summary

skin conditioning cell-communicating ingredient

Science

Mechanism of Action

The specific derivative, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, functions as a signal peptide, actively targeting and supporting critical collagens and other structural proteins located within the skin's dermal-epidermal junction (DEJ). This action stimulates the endogenous production of these vital proteins, thereby fortifying the DEJ, reducing the appearance of fine lines and wrinkles, and activating the skin's natural repair mechanisms for increased resilience and regeneration.

Research

Clinical Evidence

Medium confidence
Effective range 1–3%
Optimal

N/A

Key findings

  1. 01 Clinical observations at concentrations between 1-3% demonstrate visible skin improvements, including anti-aging benefits, enhanced firmness, and increased smoothness, attributed to its support of crucial dermal proteins.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

For general peptide stability, formulations should avoid prolonged exposure to pH levels exceeding 8. Storage in chilled or frozen aliquots is recommended to mitigate degradation pathways such as hydrolysis, oxidation, and deamidation. The palmitoyl conjugation may influence its dispersion and compatibility within diverse formulations.

Conflicts

  • Direct acids
  • Direct Vitamin C
  • Resveratrol and Ferulic Acid
  • Salicylic Acid
  • Other multi-antioxidant radiance serums

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The derivative Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine is generally regarded as safe and non-irritating, receiving a 'no penalty' rating across categories by INCI Beauty and deemed 'Irritant Free' by SkinSAFE. While general peptide safety profiles exist, a specific CIR, SCCS, or FDA safety review for this particular derivative has not been identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

DIPEPTIDE-5, particularly its Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine form, is a valuable ingredient for precision skincare, effectively targeting visible signs of aging by reinforcing skin structure with a favorable safety profile.

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