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Moumoujus

DIPEPTIDE-37.

Valuable / SKIN CONDITIONING

While initially queried as DIPEPTIDE-37, research indicates this ingredient is synonymous with Dipeptide-2 (Valyl-Tryptophan, CAS 24587-37-9). This targeted dipeptide is recognized for its ability to reduce under-eye puffiness and diminish fluid retention by supporting lymphatic circulation.

Summary

Anti-aging Eye-bag reducer Reduces puffiness Improves lymphatic circulation Calming effect

Science

Mechanism of Action

Dipeptide-2 primarily functions by enhancing lymphatic circulation, particularly in the delicate periorbital area. This action is crucial for mitigating fluid retention and reducing the appearance of under-eye puffiness and edema. Beyond fluid balance, it contributes to an improved skin texture and complexion by reducing localized inflammation and promoting overall fluid equilibrium, imparting a calming effect on the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Specific data on the typical 'dusting' concentrations for Dipeptide-2 is not available. As a targeted peptide, it is generally incorporated into formulations at functional concentrations designed to elicit a specific biological response, rather than as a bulk ingredient for general claims.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While a precise optimal pH range for Dipeptide-2 is not specified, peptides generally necessitate careful pH management for optimal stability and efficacy. Extreme pH values can lead to degradation; for instance, acid-catalyzed hydrolysis may occur at pH 1-3, peptide backbone hydrolysis at pH 5-6, and base-catalyzed epimerization above pH 7. Small peptides like Dipeptide-2 are typically freely soluble in water.

Conflicts

  • Direct acids (e.g., Alpha Hydroxy Acids, Beta Hydroxy Acids)
  • L-ascorbic acid (Vitamin C)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety assessments by bodies such as CIR, SCCS, or FDA for Dipeptide-2 have not been found. General safety profiles exist for peptides, but they do not specifically address this particular ingredient. Its overall safety profile is considered favorable in cosmetic use, albeit lacking dedicated comprehensive review.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dipeptide-2 is a valuable targeted peptide, particularly effective in formulations designed to reduce under-eye puffiness and support lymphatic drainage, though its broader anti-aging efficacy could benefit from further independent clinical research.

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