Science
Mechanism of Action
This potent micropeptide, also known as Acetyl Dipeptide-31 Amide or AP31, functions by mitigating the release of key inflammatory mediators such as IL-4, IL-6, IL-8, IL-17, and TNF-α, thereby addressing the root causes of inflammaging. Simultaneously, it significantly boosts the expression of five critical extracellular matrix (ECM) components: pro-collagen, hyaluronic acid, elastin, decorin, and fibronectin. This action leads to enhanced skin firmness, elasticity, and hydration, alongside a favorable influence on genes governing barrier function, skin plumping, epidermal metabolism, and the downregulation of cellular senescence.
Research
Clinical Evidence
High confidence0.4%
Key findings
- 01 At a 0.01% concentration, in vitro studies demonstrated statistically significant upregulation of five extracellular matrix components (pro-collagen, hyaluronic acid, elastin, decorin, fibronectin) in cultured dermal fibroblasts.
- 02 At a 0.01% concentration, ex vivo studies on human skin explants revealed significant increases in collagen III and elastin protein over 8 days.
- 03 A 16-week clinical study on 38 women utilizing a 0.4% DIPEPTIDE-31 formulated face cream showed significant improvements across 15 parameters, including reduced jawline sagging, enhanced global lift, diminished nasolabial folds, fewer fine lines and wrinkles, improved smoothness, more even skin tone, and reduced hyperpigmentation, with no reported adverse effects.
- 04 As an integral component of an AM/PM regimen, a 12-week clinical study involving 46 women observed significant improvement in early signs of pre-aging and a reduction in the skin's glycation index.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
DIPEPTIDE-31's molecular structure is optimized for superior skin penetration and absorption, ensuring consistent efficacy across various formulation types, including creams, lotions, and water-in-silicone bases.
Safety
Safety Profile
DIPEPTIDE-31 (Acetyl Dipeptide-31 Amide) has not undergone specific review by the Cosmetic Ingredient Review (CIR) Expert Panel. However, clinical studies consistently indicate it is well-tolerated and non-irritating, with no statistically significant adverse effects such as edema, erythema, dryness, or stinging reported. Preclinical studies also confirm an absence of concentration-related cytotoxicity. Due to a lack of specific data for use during pregnancy or breastfeeding, consultation with a healthcare professional is advised.
Your Skin
Skin Compatibility
Our Assessment
Verdict
DIPEPTIDE-31 is an essential micropeptide for comprehensive skin rejuvenation, offering robust anti-inflammatory and multi-faceted anti-aging benefits validated by a spectrum of in vitro, ex vivo, and human clinical studies.
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