Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

DIPEPTIDE-3.

Valuable CAS - / SKIN CONDITIONING

Dipeptide-3 encompasses a class of synthetic signaling peptides known for their multifaceted benefits in skin health. Specific derivatives are shown to either bolster the skin's intrinsic antimicrobial defense or to gently promote epidermal cell turnover, leading to enhanced overall skin quality and appearance.

Summary

Skin conditioning Exfoliant Antimicrobial protection Anti-aging Skin texture improvement Cell renewal

Science

Mechanism of Action

Dipeptides, due to their compact amino acid chains, are designed for effective skin penetration, where they act as molecular signals to instigate specific cellular responses. Acetyl Dipeptide-3 Aminohexanoate operates by stimulating the genetic expression of human beta-defensins (hBD-2 and hBD-3), which fortifies the skin's protective barrier against microbes and fosters a balanced microbiome. Conversely, Hexanoyl Dipeptide-3 Norleucine Acetate facilitates natural desquamation by competitively occupying binding sites on desmosomes, proteins crucial for epidermal cell adherence, thereby encouraging gentle exfoliation, accelerated cell renewal, and a smoother, more radiant complexion.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine®) significantly enhanced the expression of hBD-2 by 26% and hBD-3 by 10%, leading to improved antimicrobial protection for the skin.
  2. 02 Hexanoyl Dipeptide-3 Norleucine Acetate (PerfectionPeptide P3) reactivates the skin's natural desquamation process, resulting in improved skin quality, reduced irregularities and imperfections, and diminished signs of aging.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptides are inherently vulnerable to chemical degradation (e.g., hydrolysis, deamidation, oxidation, isomerization), particularly in water-based systems, and physical instability (e.g., aggregation, adsorption). Stability is influenced by the peptide's amino acid sequence, molecular weight, 3D structure, pH and buffer systems, excipients, ionic strength, temperature, humidity, light, and mechanical stress. Terminal modifications, cyclization, PEGylation, lipidation, and innovative delivery systems like microencapsulation can significantly enhance peptide stability.

Conflicts

  • Strong oxidizing agents (potential for degradation, especially for redox-sensitive peptides like copper peptides).
  • Strong reducing agents (compatibility should be validated).
  • Mismatched pH conditions (can lead to precipitation or denaturation of the peptide).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated 'DIPEPTIDE-3' as a standalone ingredient. General safety assessments exist for tissue or plant-derived peptides, but DIPEPTIDE-3 is synthetic. The SCCS (Scientific Committee for Consumer Safety) has not issued a specific opinion, and the FDA, while regulating peptide drug products, does not have a specific status for 'DIPEPTIDE-3' as a cosmetic ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dipeptide-3 offers a valuable, dual-action approach to skincare, providing both advanced antimicrobial protection and gentle exfoliation for improved skin health and appearance across all skin types.

Related

Similar Ingredients

Finding similar ingredients…