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Moumoujus

DIPEPTIDE-22.

Valuable / SKIN CONDITIONING

Dipeptide-22 is a cosmetic peptide primarily recognized for its potential in addressing hyperpigmentation. Often utilized in its more stable derivative form, Tranexamoyl Dipeptide-22, it functions as a skin conditioning agent that contributes to both skin brightening and anti-aging processes by supporting intrinsic skin repair mechanisms.

Summary

Skin conditioning Bleaching (Skin brightening) Anti-aging Pigmentation reduction Anti-inflammatory support Skin barrier enhancement

Science

Mechanism of Action

This peptide, particularly as Tranexamoyl Dipeptide-22, targets hyperpigmentation through a dual inhibitory action: it directly interferes with tyrosinase, the enzyme crucial for melanin synthesis, and concurrently suppresses the expression of MITF (microphthalmia-associated transcription factor), which is vital for the development and proliferation of melanocytes. Beyond pigmentation control, Dipeptide-22 derivatives broadly act as signal peptides, prompting the skin to activate its natural regenerative processes, thus aiding in the structural reinforcement of mature skin, promoting cell viability, reducing inflammation, and enhancing overall barrier function.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 5
0 7 14

Stability

Optimal stability for Dipeptide-22 and other peptides in aqueous solutions is typically achieved within a pH range of 3.0 to 5.0, which minimizes deamidation; however, an acceptable functional range can extend from pH 3.0 to 10.5. To facilitate dissolution, warming to room temperature or gentle sonication may be applied. If pH adjustment is required, only weak bases should be employed to preserve peptide integrity. Derivatives like Tranexamoyl Dipeptide-22 are specifically engineered for enhanced formulation stability. Challenges with skin permeability can be addressed through advanced delivery systems or molecular modifications, although the latter may impact solubility or cytotoxicity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Dipeptide-22 itself has not been individually reviewed by the CIR Expert Panel, cytotoxicity evaluations on its derivative, Tranexamoyl Dipeptide-22, indicate a favorable safety profile for topical application. The CIR has broadly deemed many tissue-derived and plant-derived proteins and peptides as safe for cosmetic use within common concentrations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dipeptide-22 offers a valuable approach to targeting hyperpigmentation and providing general skin conditioning, particularly when incorporated as a stable derivative like Tranexamoyl Dipeptide-22, making it a beneficial addition to precision skincare formulations.

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