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Moumoujus

DIPEPTIDE-2.

Valuable / SKIN CONDITIONING

Dipeptide-2 is a synthetic peptide, composed of valine and tryptophan, specifically engineered to target common concerns around the delicate eye area. It effectively addresses under-eye puffiness and dark circles while also contributing to overall skin revitalization and anti-aging benefits.

Summary

Reduces under-eye puffiness Minimizes dark circles Enhances lymphatic circulation Strengthens capillary walls Reduces wrinkle depth and volume Improves skin hydration Boosts skin elasticity Provides anti-inflammatory benefits Offers antioxidant protection Supports skin barrier function

Science

Mechanism of Action

Dipeptide-2 primarily functions by enhancing the skin's microcirculation and lymphatic drainage, thereby reducing fluid accumulation and facilitating the removal of metabolic waste that contributes to under-eye puffiness. It strengthens capillary walls to prevent leakage, further minimizing fluid retention. As an Angiotensin-Converting Enzyme (ACE) inhibitor, Dipeptide-2 reduces localized vasoconstriction, improving blood flow around the eyes. Beyond these vascular actions, it provides anti-inflammatory benefits by modulating pro-inflammatory cytokines and inhibiting NF-κB activation. The peptide also acts as an antioxidant, neutralizing free radicals, and supports skin health by stabilizing mast cells and improving barrier function. Furthermore, Dipeptide-2 functions as a natural moisturizing factor, binding water in the skin to prevent dryness, and promotes the synthesis of crucial skin proteins to visibly reduce wrinkles.

Research

Clinical Evidence

Medium confidence
Effective range 0.005–5%
Optimal

1-5%

Key findings

  1. 01 A 56-day clinical study with 20 participants demonstrated that a 3% Eyeliss™ complex, which includes Dipeptide-2, improved the reduction of under-eye bags for 70% of subjects.
  2. 02 Standalone Dipeptide-2 has suggested cosmetic benefits for anti-wrinkle and skin lifting at concentrations ranging from 0.005% to 0.7%.
  3. 03 A multi-peptide eye serum containing Dipeptide-2 showed significant reductions in wrinkle depth and volume, alongside improvements in skin hydration and elasticity over a 28-day period.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.005%
Red flag below
0.0049%

Dipeptide-2 is effective across a range of concentrations, from a suggested 0.005% for standalone benefits to an optimal 1-5% when used individually or as a component within a complex. If Dipeptide-2 is listed as a key active and its standalone concentration falls below 0.005% without being part of a specifically tested and proven complex, its efficacy may be diminished, indicating potential 'dusting' for marketing purposes.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

For optimal stability and effectiveness, Dipeptide-2 should be formulated within a pH range of 4.0 to 7.0; pH 5-6 buffers are specifically recommended to extend shelf life in peptide solutions. Solutions with pH values exceeding 8 should be frozen. It integrates best into the cool-down phase of an emulsion or directly into serums or gels, maintaining temperatures below 40°C. Protection from heat and direct sunlight is crucial for ingredient integrity.

Conflicts

  • Strong acids/alkalis
  • Strong oxidizing/reducing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Comprehensive safety assessments by regulatory bodies such as CIR, SCCS, or FDA specifically for standalone Dipeptide-2 were not found. However, it is generally considered non-irritating and suitable for sensitive skin due to its gentle mode of action.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Dipeptide-2 is a valuable peptide, particularly for the delicate eye area, effectively targeting puffiness, dark circles, and signs of aging through improved microcirculation and multi-faceted skin support mechanisms.

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