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DIPEPTIDE-10.

Valuable CAS - / SKIN CONDITIONING

DIPEPTIDE-10, specifically in its palmitoylated form (Palmitoyl Dipeptide-10), is a synthetic lipopeptide designed to promote comprehensive skin rejuvenation. It actively supports skin regeneration, enhances elasticity, and refines texture by stimulating collagen production and reinforcing the skin barrier, contributing to a visibly more youthful appearance.

Summary

Antioxidant Skin-identical ingredient Cell-communicating ingredient Skin regeneration Collagen boosting Elasticity enhancement Wrinkle reduction Barrier strengthening Anti-glycation

Science

Mechanism of Action

Palmitoyl Dipeptide-10 operates through several key mechanisms to improve skin health. It stimulates natural skin renewal processes and boosts collagen synthesis, which collectively leads to enhanced skin elasticity, improved texture, and a reduction in the appearance of wrinkles. Functioning as a potent antioxidant, it scavenges free radicals and protects dermal cells from oxidative damage. Furthermore, this lipopeptide prevents the glycation and crosslinking of structural skin proteins, thereby minimizing the formation of Advanced Glycation End products (AGEs). It is also reported to safeguard mitochondrial function, maintain stable cellular energy metabolism, and neutralize enzymes that degrade collagen. The strategic palmitoylation (conjugation with palmitic acid) is integral to its efficacy, significantly improving skin penetration and augmenting its stability against proteolytic enzymes within formulations.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The palmitoylation of Dipeptide-10 is critical for its enhanced stability within formulations and its protection against proteolytic enzymes. Peptides, including this one, exhibit pH sensitivity; degradation can accelerate in highly acidic (e.g., pH 3) or highly alkaline (e.g., pH 10) environments. Optimal stability is generally found within the pH range of 5 to 7, with specific patent data suggesting a target pH of 6.5 for robust stability.

Conflicts

  • Strong acids, such as direct acids or L-ascorbic acid, can potentially diminish the peptide's benefits due to low pH-induced degradation.
  • Strong oxidizing agents may compromise the peptide's structural integrity and efficacy.
  • Formulation with incompatible solubility profiles can lead to ingredient precipitation and reduced effectiveness.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has not formally assessed Palmitoyl Dipeptide-10, available data supports a favorable safety profile. It is rarely associated with allergic reactions or irritation and complies with European Union cosmetic directives. SkinSAFE rates it as 'Teen SAFE', 'Baby SAFE', 'Eyelid SAFE', 'Irritant Free', 'Fragrance Free', and 'Paraben Free'. The EWG Skin Deep database indicates low concern for cancer, allergies, immunotoxicity, and developmental/reproductive toxicity, though it notes limited data availability for a comprehensive assessment.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Palmitoyl Dipeptide-10 is a valuable lipopeptide for comprehensive skin rejuvenation, offering antioxidant, collagen-stimulating, and barrier-strengthening benefits with a favorable safety profile across all skin types.

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