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Moumoujus

DIPALMITOYL HYDROXYPROLINE.

Valuable CAS 41672-81-5 / ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Dipalmitoyl Hydroxyproline is a sophisticated lipoamino acid peptide engineered to significantly enhance skin's structural integrity. It targets visible signs of aging by boosting collagen synthesis and protecting vital dermal components, leading to smoother, firmer, and more elastic skin.

Summary

Skin Conditioning Anti-aging Collagen Boosting Firming Elasticity Enhancing Hydrating Antioxidant Hair Conditioning Antistatic

Science

Mechanism of Action

This ingredient functions as a potent signaling molecule that stimulates the de novo synthesis of collagen and optimizes the arrangement of existing collagen fibers within the dermis, visibly improving skin smoothness and firmness. It actively protects collagen from enzymatic degradation by inhibiting metalloproteinases (MMPs) and preserves elastin protein by reducing elastase enzyme activity. Furthermore, Dipalmitoyl Hydroxyproline enhances skin hydration by improving water retention in the epidermis and offers antioxidant protection by neutralizing free radicals and boosting the skin's natural antioxidant enzymes.

Research

Clinical Evidence

High confidence
Effective range 0.1–2%
Optimal

0.5%

Key findings

  1. 01 Demonstrated measurable improvement in wrinkle depth.
  2. 02 Reported to reduce wrinkles by up to 32% and increase skin firmness by 14%.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is not identified in research as being commonly 'dusted' or used at concentrations below its clinically effective range.

The Formula

Formulation

Solubility
Oil
Optimal pH 3.5 – 7.5
0 7 14

Stability

Dipalmitoyl Hydroxyproline appears as a white to off-white granulated powder with a faint odor, exhibiting stability under typical conditions. It requires melting and dissolution into the oil phase of a formulation at a temperature range of 80-85°C (176-185°F), with temperatures not exceeding 90°C. It is generally unsuitable for oil-free formulations.

Conflicts

  • Formulations lacking an oil phase

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

Dipalmitoyl Hydroxyproline is broadly considered safe and non-toxic in cosmetic formulations, with a low incidence of allergic reactions and no evidence of comedogenicity. While PubChem's 'Irritant' classification pertains to the raw, undiluted material, its component parts (hydroxyproline and palmitic acid) are recognized as safe. Patch testing is recommended for individuals with highly sensitive skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Dipalmitoyl Hydroxyproline is a valuable peptide for anti-aging formulations, effectively boosting collagen and elastin while providing significant firming, hydrating, and antioxidant benefits suitable for all skin types.

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