Science
Mechanism of Action
This extract exerts its effects through several key mechanisms. It demonstrates antioxidant activity by stabilizing reactive oxygen species, with specific flavonoids targeting and trapping peroxynitrite radicals. Its anti-inflammatory properties arise from the inhibition of pro-inflammatory enzymes such as phospholipase A2 and 15-lipoxygenase, actions largely attributed to its flavonoid and triterpene content. Additionally, the tannins present in the extract contribute to its noted antibacterial and antifungal capabilities.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
A 1% aqueous solution of the extract is stable within a pH range of 5.0 to 7.0, suggesting optimal stability for formulations within these parameters.
Safety
Safety Profile
Acute oral toxicity studies in animal models (mice) indicated no mortality or visible changes at 2000 mg/kg body weight, with an estimated LD50 exceeding 5 g/kg body weight, suggesting high safety in single doses. Sub-chronic toxicity studies (28 days of repeated oral treatment in rats) also found no significant toxic effects. The ingredient is generally considered safe for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Diospyros Mespiliformis Leaf Extract is a versatile botanical offering comprehensive antioxidant, anti-inflammatory, and antimicrobial benefits, making it a promising ingredient for diverse skincare formulations.
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