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DIMORPHANDRA MOLLIS POD EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Dimorphandra Mollis Pod Extract is a botanical ingredient derived from the pods of the Dimorphandra mollis plant, distinguished by its high concentration of beneficial flavonoids such as rutin and quercetin. It is primarily valued for its potent antioxidant and anti-inflammatory capabilities, supporting cellular protection against oxidative stress and modulating inflammatory responses in the skin.

Summary

skin conditioning antioxidant anti-inflammatory photoprotective vasoprotective

Science

Mechanism of Action

This extract functions primarily through its rich flavonoid content, including rutin, quercetin, and astilbin. These compounds act as potent scavengers of DPPH and ABTS radicals, effectively neutralizing reactive oxygen species (ROS) and reducing cellular damage as evidenced by decreased malondialdehyde (MDA) levels and enhanced glutathione (GSH) production. Its anti-inflammatory action involves inhibiting myeloperoxidase (MPO) activity and modulating inflammatory pathways by reducing markers such as IL-6, IL-10, NOS2, and PTGS2, which in turn decreases cyclooxygenase enzyme activity and neutrophil infiltration. Additionally, the high rutin content is believed to impart vasoprotective benefits, strengthening capillary integrity and improving microcirculation. The extract has also demonstrated photostability, allowing the sustained release of its flavonoid components into the skin, suggesting inherent photoprotective properties.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A formulation containing Dimorphandra mollis extract demonstrated an SPF of 2.3 ± 0.4 and exhibited photostability, facilitating the release of flavonoids into the skin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 6
0 7 14

Stability

The active flavonoids within the extract are susceptible to degradation from exposure to heat and light, which can compromise their chemical stability and potentially lead to product discoloration. To maintain optimal efficacy, it is crucial to formulate this ingredient within an acidic to slightly acidic pH range of 2.0 to 6.0. Micro- and nanoencapsulation techniques are suggested as effective strategies to enhance the stability of the extract's active compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Dimorphandra Mollis Pod Extract is currently listed as 'not reviewed' by the Cosmetic Ingredient Review (CIR), indicating it is awaiting or undergoing assessment. There is no specific safety assessment available from the SCCS for topical application. While the FDA does not mandate pre-market approval for cosmetic ingredients, manufacturers are responsible for product safety. Oral toxicity studies in rodents indicated safety at 1000 mg/kg, but further research was suggested for 2000 mg/kg, with caution for long-term oral use. This oral safety data is not directly applicable to topical cosmetic use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dimorphandra Mollis Pod Extract is a valuable botanical ingredient, rich in potent flavonoids, offering significant antioxidant and anti-inflammatory benefits across all skin types, with potential for photoprotection, though further topical clinical efficacy data and regulatory review are pending.

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