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DIMETHYLAMINOPROPYLAMINO HYPOCRELLIN B.

Avoid CAS - / DEPILATORY

DIMETHYLAMINOPROPYLAMINO HYPOCRELLIN B is a synthetic derivative of natural Hypocrellin B, engineered to optimize properties like water solubility and enhance photodynamic activity. It is exclusively researched for its application as a photosensitizer in targeted therapeutic contexts.

Summary

Science

Mechanism of Action

This compound acts as a photosensitizer. Upon irradiation with light, it generates reactive oxygen species (ROS), including singlet oxygen (¹O₂) and superoxide anion radicals (O₂*-). This light-activated process leads to cytotoxic effects, inducing apoptosis and necrosis, primarily within the framework of photodynamic therapy (PDT) for treating various cancers.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 DIMETHYLAMINOPROPYLAMINO HYPOCRELLIN B (HBDP-R1) was selected for preclinical evaluation based on its optimal in vitro cyto- (dark) toxicity and phototoxicity profiles.
  2. 02 Related Hypocrellin B derivatives, such as PENSHB, exhibited significantly improved water solubility (6.6 mg/ml) compared to parent HB (4.6 µg/ml). In vitro, these derivatives demonstrated a superior photodynamic therapy (PDT) effect, inducing mitochondrial inner membrane permeabilization, cytochrome c release, and caspase-3 activation, culminating in apoptotic cell death. In vivo studies indicated that PENSHB-mediated PDT cured over 50% of tumor-bearing mice.

Transparency

Dusting Analysis

Not commonly dusted

There is no indication of this ingredient being commonly 'dusted' in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While derivatives are designed for improved water solubility and stability compared to the parent hydrophobic Hypocrellin B, this compound is inherently a photosensitizer. It is prone to photobleaching in the presence of oxygen when exposed to light, necessitating careful formulation to prevent degradation.

Conflicts

  • light
  • oxygen (during light exposure)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

DIMETHYLAMINOPROPYLAMINO HYPOCRELLIN B and its derivatives are primarily investigated for medical photodynamic therapy, leveraging their light-activated cytotoxic properties against tumor cells. No safety assessments by cosmetic regulatory bodies such as CIR, SCCS, or FDA are available for general cosmetic skincare applications. Its core mechanism involves inducing cell death, which is contrary to the objectives of cosmetic skincare. Rigorous evaluation is required for medical use, underscoring its unsuitability for general cosmetic formulations. A related derivative (HBBA-R2) was found to be non-mutagenic in specific tests, but this does not cover broader cosmetic safety concerns.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

DIMETHYLAMINOPROPYLAMINO HYPOCRELLIN B is a photosensitizer with documented cytotoxic effects in therapeutic cancer research, entirely lacking safety and efficacy data for general cosmetic skin applications, and posing significant risks due to its intended mechanism of action.

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