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DIMETHYLAMINOPROPYLAMIDO PCA DIMETHICONE.

Valuable CAS 179005-02-8 / HAIR CONDITIONING, SKIN CONDITIONING

DIMETHYLAMINOPROPYLAMIDO PCA DIMETHICONE is an organosilicon compound designed to impart long-lasting emolliency and a luxurious silky after-feel to the skin. It forms a protective, vapor-permeable film that effectively reduces transepidermal water loss, thereby significantly boosting skin hydration and promoting a supple complexion.

Summary

Emollient Occlusive Humectant Skin Protectant

Science

Mechanism of Action

This organosilicon acts by forming a breathable, protective film on the skin's surface, which functions as an occlusive agent to minimize transepidermal water loss (TEWL). This action directly enhances skin hydration. The ingredient incorporates a pyrrolidone carboxylic acid (PCA) group, an isomer of a natural moisturizing factor, which crucially lowers the interfacial tension between water and silicone. This PCA component also exhibits a high affinity for keratin proteins, enabling it to bind multiple units of moisture and form ionic bonds with free amino groups, further contributing to the skin's moisture retention and overall smoothness.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

DIMETHYLAMINOPROPYLAMIDO PCA DIMETHICONE demonstrates excellent solubility in lower pH formulations and maintains functionality across a broad pH range, making it suitable for neutral to low pH personal care systems. An optimal pH range of 4.5 to 7.0 is recommended for maximizing its slip properties.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
85%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that dimethicone and its substituted-methicone polymers, including this ingredient, are safe for cosmetic use when formulated to be non-irritating. The maximum reported concentration for dermal application is 85%. While the CIR has re-opened the safety assessment to gather further data on particle size distribution and inhalation toxicity for products that may be incidentally inhaled, the dermal safety conclusion for non-irritating formulations remains robust. Dimethicone, a related compound, is recognized by the FDA as an active ingredient in OTC skin protectants.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This organosilicon is a valuable ingredient, offering superior hydration, emolliency, and a protective barrier suitable for all skin types due to its low irritancy and comedogenicity.

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