Science
Mechanism of Action
This cyclodextrin derivative primarily functions by forming host-guest inclusion complexes. Its lipophilic internal cavity encapsulates hydrophobic molecules, while its hydrophilic exterior ensures water solubility. This mechanism allows it to increase active ingredient solubility and stability, protect against degradation from light, heat, or oxidation, facilitate controlled and sustained release, and significantly improve skin penetration. Additionally, it acts as an emulsion stabilizer, supporting product integrity, and as a surfactant, aiding in gentle cleansing.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data suggests Dimaltosyl Cyclodextrin is commonly subject to dusting or used at concentrations warranting such a concern within cosmetic contexts.
The Formula
Formulation
Stability
While no specific optimal pH range is defined for Dimaltosyl Cyclodextrin, general cyclodextrin characteristics suggest stability under alkaline conditions. Acid hydrolysis can occur at low pH, leading to ring degradation. Stability of some cyclodextrin complexes has been observed within a neutral pH range (7.0-7.4).
Synergies
- Enhances solubility and stability of various hydrophobic active ingredients.
- Improves bioavailability and skin penetration of active compounds.
Conflicts
- Potential competitive complexation with other excipients within a formulation.
- May modulate the permeability of co-administered medicinal substances.
Safety
Safety Profile
Dimaltosyl Cyclodextrin has not been specifically evaluated by the CIR Expert Panel. However, related cyclodextrin derivatives, including native cyclodextrins, 2-hydroxypropyl-β-cyclodextrin, and hydroxyethyl-β-cyclodextrin, have been deemed safe for cosmetic use. Human volunteer studies indicate natural cyclodextrins are well-tolerated at concentrations up to 0.1%. The U.S. FDA generally recognizes alpha-, beta-, and gamma-cyclodextrins as safe (GRAS). General cyclodextrin safety data suggests low risk at typical cosmetic concentrations, though high oral or parenteral doses in animals have shown potential for digestive or renal issues, respectively.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Dimaltosyl Cyclodextrin is a valuable excipient, significantly enhancing formulation efficacy by improving active ingredient delivery and stability while maintaining broad compatibility, especially for sensitive skin.
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References
Sources