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Moumoujus

DIHYDROCHOLESTERYL BUTYRATE.

Valuable CAS 59000-59-8 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Dihydrocholesteryl Butyrate is a cholesterol ester of butyric acid, functioning as a derivative of the postbiotic butyrate. It offers significant benefits by modulating inflammatory responses and strengthening the skin's natural barrier.

Summary

Anti-inflammatory Barrier Support Immunomodulation Protective Nourishing

Science

Mechanism of Action

This ingredient acts as a histone deacetylase (HDAC) inhibitor and signals through G-protein coupled receptors to suppress pro-inflammatory cytokines such as IL-1 and TNF-α. It also enhances keratinocyte metabolism and differentiation, promoting the production of key structural components like filaggrin and KRT1 for improved barrier function.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for Dihydrocholesteryl Butyrate was identified. However, formulation strategies may be needed for general butyrate compounds to mask unfavorable sensorial properties.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Dihydrocholesteryl Butyrate lacks specific CIR, SCCS, or FDA assessments, general butyrate for topical application is considered safe with no noted toxic or side effects.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This butyrate derivative offers significant potential for enhancing skin barrier function and modulating inflammatory responses, especially beneficial for dry and sensitive skin types.

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