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DIETHYL SUCCINATE.

Questionable CAS 123-25-1 / FRAGRANCE, PLASTICISER, SKIN CONDITIONING - EMOLLIENT, SOLVENT

An oil-soluble ester functioning as an emollient and solvent. It helps enhance skin suppleness and hydration while dissolving other formulation ingredients.

Solvent Emollient Fragrance

Science

It conditions the skin by improving its hydration and texture. Beyond this, in vitro studies suggest it may offer inflammatory protective effects by modulating microglial activation and reducing cellular stress.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The compound is moderately heat-stable, but strong acids, bases, or moisture can accelerate its hydrolysis, potentially forming unpleasant odors or acidic byproducts.

Conflicts

  • strong acids
  • strong alkalis
  • strong oxidizing agents
  • strong reducing agents
  • moisture

Safety

CIR Status
Reviewed
Sensitization risk Moderate

Reviewed by CIR and deemed safe for limited use in food by the FDA as a flavoring agent. While generally low in systemic toxicity, it is a mild skin irritant and can cause serious eye irritation.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

While it functions as a useful solvent and emollient, its potential for skin and serious eye irritation, alongside a lack of specific cosmetic safety limits and clinical efficacy data, warrants careful consideration.


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