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Moumoujus

DIETHYL KETOGLUTARATE.

Insufficient Data / SKIN CONDITIONING, SKIN PROTECTING

Diethyl Ketoglutarate is an ester designed to deliver alpha-ketoglutarate (AKG) to the skin. It aims to enhance skin hydration, strengthen barrier function, and offer antioxidant protection while supporting collagen metabolism.

Summary

Antioxidant Skin Barrier Support Hydration Collagen Support Anti-aging

Science

Mechanism of Action

Diethyl Ketoglutarate rapidly hydrolyzes to alpha-ketoglutarate (AKG) in skin. AKG promotes hydration and barrier function via cell proliferation and epidermal gene expression, acts as an antioxidant, and stimulates collagen while inhibiting hyaluronidase to maintain skin firmness.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The ingredient exists in equilibrium between its 2-keto and hydrate forms. While its ester form has limited water solubility, it has been observed in water at pH 7 for research purposes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific cosmetic safety assessments exist for Diethyl Ketoglutarate. Its precursor, AKG, showed no toxicity to human dermal fibroblasts at concentrations up to 100 µM, suggesting a high safety profile for topical application.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While promising in its hypothesized mechanism, direct clinical data and comprehensive safety assessments for Diethyl Ketoglutarate as a cosmetic ingredient are currently insufficient to make a definitive recommendation.

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