Science
Mechanism of Action
This extract reduces multiple inflammatory cytokines including IL-17, IFN-γ, and TNF-α, while inhibiting immune cell infiltration. It modulates key signaling pathways like NF-κB, STAT1/3, and ERK/p38 MAPK, additionally decreasing mast cell degranulation and boosting skin hydration.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In imiquimod-induced psoriasis models, a methanol extract reduced IL-17 cytokine levels by 44.37%, alleviating scaly skin, immune cell infiltration, and epidermal hyperplasia.
- 02 Across various dermatitis mouse models (psoriasis, atopic, allergic, contact), extracts consistently suppressed inflammatory markers such as TNF-α, IFN-γ, IL-4, IL-5, IL-6, IL-1β, IL-8, TSLP, and MCP-1.
- 03 Demonstrated improvement in skin barrier function by increasing skin water content and water holding capacity, and reduced histamine and β-hexosaminidase release in allergic reactions.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not explicitly reviewed this extract. Topical application in animal studies suggests relative safety without reported skin adverse reactions, however, oral administration of aqueous extracts showed sub-chronic toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Dictamnus Dasycarpus Root Extract is a valuable ingredient for addressing various inflammatory and allergic skin concerns, consistently demonstrating benefits for barrier function and skin soothing in preclinical models.
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References
Sources