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DIBROMOHEXAMIDINE ISETHIONATE.

Valuable CAS 93856-83-8 / PRESERVATIVE

DIBROMOHEXAMIDINE ISETHIONATE is a highly effective cosmetic preservative, crucial for inhibiting microbial growth and maintaining product integrity. Skin safety assessments consistently rate it as non-irritant at concentrations up to 0.5%.

Summary

Preservative

Science

Mechanism of Action

It functions by creating an environment unfavorable for the proliferation of various microorganisms, including bacteria and fungi. This ensures cosmetic products remain stable and safe throughout their shelf life.

Research

Clinical Evidence

High confidence
Effective range 0.2–0.5%
Optimal

N/A

Key findings

  1. 01 Rabbit skin safety assessments by SCCNFP found the ingredient non-irritant at 0.2% and 0.5% concentrations.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Preservatives are essential for water-containing cosmetic formulations to prevent microbial spoilage, with manufacturers typically using the lowest effective concentration for optimal shelf life and safety.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The CIR Expert Panel concluded DIBROMOHEXAMIDINE ISETHIONATE is safe as used when formulated to be non-irritating. While non-irritant to rabbit skin at 0.2% and 0.5%, it caused slight irritation in rabbit eyes.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

DIBROMOHEXAMIDINE ISETHIONATE is a valuable preservative, crucial for maintaining product stability and safety against microbial contamination, with a strong skin safety profile at typical usage concentrations.

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