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Moumoujus

DESMODIUM ADSCENDENS EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Desmodium Adscendens Extract is a multi-functional botanical ingredient, rich in diverse phytochemicals, that delivers significant antioxidant protection and anti-inflammatory benefits to the skin. It effectively soothes irritated complexions by reducing redness and combating oxidative stress, making it particularly beneficial for sensitive and reactive skin types.

Summary

Skin conditioning Antioxidant Soothing Anti-inflammatory

Science

Mechanism of Action

This extract exerts its dermatological benefits through a synergistic blend of phytochemicals, including flavonoids, isoflavonoids, alkaloids, terpenoids, and phenols, with quercetrin dihydrat identified as a key phenolic compound. Its antioxidant capacity arises from inhibiting free radical generation and upregulating crucial endogenous antioxidant enzymes such as Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione (GSH). The anti-inflammatory action is hypothesized to involve the inhibition of histamine release via histidine decarboxylase enzymatic activity, and the modification of vascular inflammatory mechanisms due to its high concentration of flavonoids.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of a hydroglyceric extract demonstrated a mean blanching effect of 48.8% on artificially evoked erythema in volunteers with Type I Contact Dermatitis, indicating potent anti-redness capabilities.
  2. 02 In an in vitro study, Desmodium adscendens extract, at a concentration of 25 mg/mL, achieved a substantial reduction of intracellular Reactive Oxygen Species (ROS) levels by 83.2 ± 6.21%, highlighting its strong antioxidant potential.

Transparency

Dusting Analysis

Not commonly dusted

Based on available research demonstrating specific mechanisms of action and measurable clinical outcomes, Desmodium Adscendens Extract does not appear to be commonly 'dusted' in formulations but rather included for its active properties.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Extracts exhibit stability for a minimum of 24 hours when stored at 4°C. This ingredient is typically formulated as aqueous or hydroglyceric extracts.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessment has been conducted by the CIR (Cosmetic Ingredient Review) or SCCS (Scientific Committee on Consumer Safety) for cosmetic application. In vitro studies suggest that lower concentrations (1-10 mg/mL) are well-tolerated by liver and kidney cells. While a very high in vitro concentration (100 mg/mL) decreased cell viability by 40%, a human topical study observed a beneficial blanching effect on induced erythema, suggesting low irritancy and potential soothing properties at relevant cosmetic concentrations. Acute oral toxicity in animal models indicated relatively low systemic toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Desmodium Adscendens Extract is a valuable botanical ingredient, providing scientifically supported antioxidant defense and significant soothing benefits for reactive skin by effectively reducing redness and inflammation.

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