Science
Mechanism of Action
Dendropanax Morbiferus Extract (DME) operates through several key pathways to enhance skin health. As a powerful antioxidant, it actively neutralizes reactive oxygen species (ROS) and scavenges DPPH radicals, displaying superoxide dismutase (SOD)-like activity to combat oxidative stress and prevent premature aging. Its anti-inflammatory actions involve reducing nitric oxide (NO), inducible NO synthase, and various interleukin markers, while suppressing NF-κB and TNF-α nuclear translocation to mitigate inflammatory conditions. For anti-hyperpigmentation, DME inhibits tyrosinase activity and melanin formation. Furthermore, it exhibits broad-spectrum antimicrobial efficacy against common skin pathogens, and contributes to anti-aging by improving collagen synthesis, reducing denatured elastin, and modulating matrix metalloproteinase (MMP) activity, while also providing moisturizing benefits.
Research
Clinical Evidence
High confidenceEfficacy for antioxidant benefits is observed effectively in the range of 0.001% to 0.05% (10 to 500 µg/mL), with significant DPPH-radical scavenging at 0.05%. Antimicrobial benefits require higher concentrations, for instance, 0.313% to 0.625% for specific bacteria, and 20% for fermented extract. A precise optimal single percentage is not provided, as different benefits are achieved at varying concentrations.
Key findings
- 01 Inhibited intracellular active oxygen production against hepatocellular injury, demonstrating antioxidant efficacy.
- 02 Displayed significant 2,2-dipheny-l-picrylhydrazyl (DPPH)-radical scavenging activity, further confirmed with 82.92 ± 0.49% activity at 0.05% (500 µg/mL).
- 03 Demonstrated Minimum Inhibitory Concentration (MIC) against Porphyromonas gingivalis for hot water and ethanol extracts, respectively, highlighting antimicrobial action.
- 04 A fermented extract exhibited strong antimicrobial effects against Staphylococcus epidermidis and Staphylococcus aureus.
Transparency
Dusting Analysis
Dendropanax Morbiferus Phytoplacenta Extract exhibits demonstrable efficacy across a broad range of concentrations, from as low as 0.001% for antioxidant benefits to 20% for strong antimicrobial effects. This wide spectrum of functional concentrations, depending on the desired skin benefit, suggests that its inclusion in formulations is typically for targeted benefits at effective levels, rather than merely for 'label claim' purposes.
The Formula
Formulation
Stability
While specific optimal pH ranges are not documented, the extract is commonly prepared using polar solvents like water or ethanol. It is amenable to formulation with various cosmetic additives, including stabilizers, humectants, emulsifiers, and pH adjusters, supporting its integration into diverse product types.
Safety
Safety Profile
This extract has not been formally reviewed by CIR, SCCS, or FDA. However, scientific studies consistently indicate high biocompatibility and low toxicity, with cell viability exceeding 85% even at concentrations below 0.02% (<0.2 mg/mL). Its historical use as a food additive and in traditional medicine further supports a favorable safety profile, with no reported side effects in studies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile botanical ingredient, Dendropanax Morbiferus Phytoplacenta Extract provides comprehensive skin benefits, effectively targeting oxidative stress, inflammation, hyperpigmentation, microbial imbalances, and signs of aging with a strong safety profile.
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References
Sources