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Moumoujus

DENDROPANAX MORBIFERUS EXTRACT.

Valuable CAS - / HAIR CONDITIONING, SKIN CONDITIONING

Dendropanax Morbiferus Extract, derived from the 'Hwangchil tree', is a multi-functional ingredient known for its significant anti-hyperpigmentation, anti-inflammatory, and antioxidant properties. It actively reduces melanin production, soothes skin inflammation, and offers protective benefits against environmental stressors, while also exhibiting moisturizing and antimicrobial effects for comprehensive skin health.

Summary

Anti-hyperpigmentation Anti-inflammatory Antioxidant Anti-aging Antimicrobial Moisturizing Skin conditioning Hair conditioning

Science

Mechanism of Action

Dendropanax Morbiferus Extract (DME) primarily acts through multifaceted biological pathways. It exhibits anti-hyperpigmentation by effectively inhibiting tyrosinase enzyme activity and subsequently reducing melanin synthesis. Its potent anti-inflammatory action is demonstrated by the suppression of key pro-inflammatory cytokines such as TNF-α and IL-6, along with a decrease in nitric oxide (NO) production, which collectively mitigates inflammatory responses. As a robust antioxidant, DME efficiently scavenges reactive oxygen species (ROS), bolstering the skin's natural defense system. Furthermore, it contributes to anti-aging by promoting skin wrinkle improvement, provides moisturizing benefits through reducing transepidermal water loss (TEWL), and offers broad-spectrum antimicrobial activity against various bacteria and fungi.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibits melanin production and reverses metabolite alterations, showing highest efficacy for skin brightening.
  2. 02 An isolated component (1-tetradecanol) significantly reduced transepidermal water loss (TEWL) by 30% compared to control in HR-1 hairless mice, indicating moisturizing properties.
  3. 03 Demonstrated antibacterial effects against S. mutans and C. albicans.
  4. 04 Exhibited strong antimicrobial effects against S. epidermidis and S. aureus.
  5. 05 Achieved minimum inhibitory concentrations (MIC) for eliminating Porphyromonas gingivalis at 3.13 mg/mL (hot water extract) and 6.25 mg/mL (ethanol extract).

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest dusting of this ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract demonstrates good stability, indicated by a coefficient of variation (CV) of less than 30%.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Ministry of Food and Drug Safety, Korea Food and Drug Administration, has registered various parts of Dendropanax morbifera as food additives and alternative folkloric medicine. Studies consistently indicate low cytotoxicity and high biocompatibility. In vivo studies mitigating inflammatory dermatitis observed no reported side effects, and ingredient databases like INCI Beauty assign 'No penalty' in all categories, suggesting a favorable safety profile for cosmetic application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Dendropanax Morbiferus Extract is a valuable ingredient, offering comprehensive benefits including anti-hyperpigmentation, anti-inflammatory, antioxidant, and moisturizing effects, suitable for a wide range of skin types with a low risk of irritation or comedogenicity.

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