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Moumoujus

DENDROBIUM MONILIFORME CALLUS CULTURE EXTRACT.

Valuable / SKIN CONDITIONING

Dendrobium Moniliforme Callus Culture Extract is derived from the undifferentiated cell mass of the Dendrobium orchid. Rich in beneficial compounds, it is recognized for its potential antioxidant and skin conditioning properties, contributing to skin hydration and protection against environmental stressors.

Summary

Skin Conditioning

Science

Mechanism of Action

This extract contains an array of active compounds, including water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenols. These constituents are recognized for their antioxidant capabilities. Specifically, a related Dendrobium orchid polysaccharide extract has demonstrated efficacy in reducing intracellular reactive oxygen species (ROS) induced by UVB irradiation and enhancing skin hydration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A Dendrobium orchid polysaccharide extract was found to be safe for human skin cells within a concentration range of 6.25-100 µg/mL. This extract effectively decreased intracellular ROS levels induced by UVB irradiation and demonstrated skin hydrating efficacy. It is important to note this study refers to a 'Dendrobium orchid polysaccharide extract', not specifically the 'callus culture extract'.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Formulations incorporating a 'Dendrobium orchid polysaccharide extract' with a solvent system of Tween 80:ethanol (5:1), water, and isononyl isononanoate have exhibited desirable physical and chemical stability. Specific optimal pH ranges for the stability of this exact callus culture extract in cosmetic formulations are not currently defined.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

An acute oral toxicity study of Dendrobium moniliforme aqueous extract (DMAE) in rats showed no adverse effects at single doses up to 5,000 mg/kg body weight, with a minimal lethal dose exceeding 5,000 mg/kg. In vitro cytotoxicity tests on human embryonic kidney (HEK293) cells indicated cell death above 6 mg/mL, and viability decreased to less than 50% following 24-hour exposure to 10 mg/mL of the aqueous extract. While related extracts have been deemed safe for human skin cells in specific studies, general sensitization risk is unknown.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This extract demonstrates valuable potential for antioxidant protection and hydration, supported by studies on related Dendrobium extracts, though further direct clinical research on the specific callus culture extract would enhance precision in its application.

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References

Sources