Science
Mechanism of Action
This callus extract functions as a genomic activator for skin barrier proteins, specifically upregulating filaggrin and tight-junction proteins like claudin-1 and occludin to prevent trans-epidermal water loss. It concurrently inhibits the release of pro-inflammatory cytokines (TNF-α and IL-1β) and nitric oxide, effectively quenching oxidative stress and neutralizing redness at the source.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 In vivo testing on 21 subjects demonstrated significant improvements in skin elasticity and barrier function (via TEWL reduction) after 14 days of application.
- 02 Concentrations of 1.0% and 5.0% showed immediate and significant short-term hydrating efficacy in human volunteers without any adverse reactions.
Transparency
Dusting Analysis
While anti-inflammatory benefits are observed at levels as low as 0.02%, therapeutic barrier repair and measurable hydration typically require concentrations above 1.0%. Formulations using this at 'label-only' levels (below 0.1%) fail to utilize its primary humectant and structural benefits.
The Formula
Formulation
Stability
Highly stable for up to 24 months when protected from direct UV exposure and stored in airtight conditions.
Synergies
- Hyaluronic Acid
- Ceramides
- Niacinamide
Safety
Safety Profile
Listed in the Inventory of Existing Cosmetic Ingredients in China; clinical trials on human volunteers confirm zero irritancy and excellent biocompatibility even at 5.0%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent, bio-engineered botanical that excels at boosting skin resilience and internal hydration through protein upregulation.
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References
Sources