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Moumoujus

DEER ANTLER CELL/SH-POLYPEPTIDE-1 CONDITIONED MEDIA.

Valuable / HAIR CONDITIONING, SKIN CONDITIONING

DEER ANTLER CELL/SH-POLYPEPTIDE-1 CONDITIONED MEDIA is a sophisticated bioactive complex derived from deer antler stem cells, enriched with the growth factor SH-Polypeptide-1 (bFGF). It harnesses a potent blend of signaling molecules to promote advanced skin regeneration and rejuvenation. This ingredient aims to activate cellular repair mechanisms, significantly enhancing skin structure and overall appearance.

Summary

Skin conditioning Cell-signaling Stimulates fibroblast growth and proliferation Stimulates collagen and extracellular-matrix synthesis Anti-aging Wound healing Skin regeneration Hair regeneration support

Science

Mechanism of Action

This conditioned media primarily functions through paracrine effects, delivering a rich array of bioactive molecules to skin cells. These include essential cytokines, growth factors such as SH-Polypeptide-1 (also known as Basic Fibroblast Growth Factor or bFGF), noncoding RNAs, and extracellular vesicles. SH-Polypeptide-1 specifically stimulates the growth and proliferation of fibroblasts, which are crucial for synthesizing collagen and other extracellular matrix components. It also works to decrease levels of matrix metalloproteinase-1 (MMP-1) while simultaneously increasing procollagen type 1, thereby actively mitigating wrinkle formation. Beyond these actions, the conditioned media promotes angiogenesis, stimulates the proliferation, migration, and differentiation of resident skin cells, and supports the functional recovery of cellular metabolism. A key aspect of its regenerative potential involves the activation of the Wnt signaling pathway, which is vital for both skin and hair regeneration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a mouse model, a serum containing deer antler stem cell extract demonstrated significant anti-aging effects after 2 weeks, reducing the number of wrinkles by 48.09% (compared to commercial serum) and 60.31% (compared to positive control). It also accelerated skin recovery time by 39.31% to 67.1%, increased collagen density by 10.18% to 63.76%, and enhanced epidermal thickness by 106.1% to 121.7%.
  2. 02 In vitro studies showed Antler Stem Cell-Conditioned Medium (ASC-CM) significantly stimulated the proliferation of human umbilical vein endothelial cells (HUVEC) and mouse embryonic fibroblast (NIH-3T3) cells.
  3. 03 In vivo rat studies indicated ASC-CM accelerated wound closure effectively, completing healing on day 16 (± 3 days), which was 9 days (± 2 days) earlier than the control group. The treated wound area was significantly smaller (p < 0.05), and healing quality was enhanced by increasing the ratios of Col3A1/Col1A2, TGF-β3/TGF-β1, MMP1/TIMP1, and MMP3/TIMP1.
  4. 04 Deer Antler-derived Mesenchymal Stem Cell-conditioned media (DaMSC-CM) enhanced hair regeneration by activating the Wnt signaling pathway and exhibited regenerative potential in damaged skin tissue by inducing skin regeneration-related genes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A serum product formulated with deer antler stem cell extract in a coconut oil foundation has been reported to exhibit high stability.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA for DEER ANTLER CELL/SH-POLYPEPTIDE-1 CONDITIONED MEDIA are not available. Preclinical studies utilizing antler stem cells or their conditioned media have generally reported no adverse effects.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

With substantial preclinical evidence demonstrating significant anti-aging, regenerative, and wound-healing capabilities, this ingredient presents valuable potential for advanced skincare, pending further human clinical and comprehensive safety data.

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