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Moumoujus

DECAPEPTIDE-53 AMIDE.

Insufficient Data / ANTIMICROBIAL

A specialized ten-amino acid synthetic peptide designed to support the skin's surface integrity. It primarily serves as a targeted antimicrobial agent, assisting in the management of the skin's delicate microbiome to prevent the proliferation of unwanted bacteria and fungi.

Summary

Antimicrobial Skin Conditioning Microbiome Support

Science

Mechanism of Action

Decapeptide-53 Amide acts by disrupting the cell membranes or metabolic pathways of specific microorganisms, effectively controlling microbial growth on the skin surface. This bio-active approach helps maintain a balanced environment, which is crucial for preventing congestion and inflammation associated with bacterial imbalances.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.001%
Red flag below
0.0001%

As a high-potency peptide, it is frequently included in formulations at negligible concentrations for marketing purposes. While antimicrobial peptides are effective at low doses, 'dusting' occurs when it is listed near the bottom of the INCI without achieving a functional threshold for microbial control.

The Formula

Formulation

Solubility
Unknown
Optimal pH 4 – 6
0 7 14

Stability

Like most peptides, it is sensitive to extreme pH levels and high temperatures. General stability for similar amides is often optimized in slightly acidic environments near pH 4.5.

Synergies

  • Preservative boosters
  • Soothing agents
  • Barrier-repair lipids

Conflicts

  • Strong proteolytic enzymes
  • High concentrations of AHAs/BHAs (potential destabilization)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The CIR has not specifically evaluated this peptide. While related peptides are generally considered safe in low concentrations, specific toxicological data for the decapeptide-53 sequence is currently limited.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

A promising antimicrobial peptide that requires further independent clinical validation to confirm its specific efficacy and safety profile in skincare.

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