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Moumoujus

DECAPEPTIDE-3.

Valuable CAS - / SKIN CONDITIONING

DECAPEPTIDE-3 is a synthetic biomimetic peptide designed to mimic the regenerative actions of basic Fibroblast Growth Factor (bFGF). It functions as a cell-communicating ingredient, promoting skin development, repair, and overall dermal health.

Summary

Anti-aging Cell-communicating ingredient Skin regeneration Melanocyte proliferation Improves skin elasticity Reduces fine lines and wrinkles

Science

Mechanism of Action

As a signal peptide, DECAPEPTIDE-3 activates specific receptors on skin cells, initiating cascades that boost the synthesis of extracellular matrix (ECM) proteins, including collagen, fibronectin, and laminin. This action supports the proliferation of fibroblasts, endothelial cells, and keratinocytes, while also offering cellular protection. The cumulative effect is a reduction in the appearance of fine lines and wrinkles, enhanced skin elasticity, and a firmer, more supple complexion. Furthermore, in the context of vitiligo, this decapeptide has been observed to stimulate the migration and growth of melanocytes, the cells responsible for melanin production, thereby aiding in the restoration of skin pigmentation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.1%

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine common dusting practices or thresholds for DECAPEPTIDE-3.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

DECAPEPTIDE-3 exhibits stability for 24 months when stored at -20°C to -15°C, provided it is protected from light and kept in an airproofed container when not in use. General peptide stability can be compromised by factors such as extreme pH levels, high salt concentrations, elevated temperatures, and proteolytic degradation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not specifically reviewed DECAPEPTIDE-3 under its current INCI name. While a past CIR assessment for 'Acetyl Hexapeptide-8 Amide' (which had a retired synonym 'Acetyl Hexapeptide-3') indicated safety up to 0.005%, this assessment explicitly excludes the current DECAPEPTIDE-3. No specific SCCS opinion or FDA status for DECAPEPTIDE-3 as a cosmetic ingredient was found.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

DECAPEPTIDE-3 is a valuable signal peptide with a strong mechanism for promoting skin regeneration and improving signs of aging, alongside promising clinical data for specific re-pigmentation needs, although broader cosmetic safety assessments are currently unavailable.

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