Science
Mechanism of Action
This precision peptide operates by stimulating the proliferation and migration of melanocytes, thereby facilitating the re-pigmentation of skin. Additionally, DECAPEPTIDE-14, as a 'peptide 14', has been observed to mitigate the accumulation of DNA damage and prevent cellular senescence through its influence on FoxO and cellular senescence signaling, contributing to its anti-aging benefits.
Research
Clinical Evidence
Medium confidence0.1%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptides generally exhibit enhanced dissolution and greater charge at a near-neutral pH range of 6-8. While beta-peptides can show decreased helicity and stability at higher pH levels (e.g., 7.4-9.6) and some sensitivity at very low pH (e.g., 1.8), careful pH management is key for optimal stability and efficacy.
Conflicts
- Glycerol (due to potential Maillard reactions that can lead to peptide degradation)
Safety
Safety Profile
Although DECAPEPTIDE-14 lacks specific review by the CIR Expert Panel, peptides generally have a favorable safety profile. Clinical studies utilizing a 0.1% concentration of a bFGF-related decapeptide demonstrated excellent tolerability, with only a minimal percentage of patients experiencing mild, transient side effects such as erythema or a burning sensation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
DECAPEPTIDE-14 is a valuable peptide for precision skincare, demonstrating strong clinical efficacy in stimulating re-pigmentation and showing promise in anti-aging applications, with a favorable tolerability profile.
Related
Similar Ingredients
Finding similar ingredients…