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Moumoujus

DAPHNE ODORA CALLUS EXTRACT.

Valuable / SKIN PROTECTING

Daphne Odora Callus Extract is a botanical ingredient derived from the Daphne odora plant, rich in beneficial lignans and flavonoids. It is recognized for its potent ability to improve skin moisture, accelerate healing, and protect against environmental stressors, particularly cold conditions. This extract offers significant anti-inflammatory, antioxidant, and overall skin-protecting functions.

Summary

Skin Protecting Anti-inflammatory Antioxidant Hydrating Healing Barrier Support Circulation Boosting

Science

Mechanism of Action

This extract operates on multiple biological pathways to enhance skin health. It induces the sebum regulator 5αR1 in fibroblasts and significantly inhibits the expression of key inflammatory cytokines (IL-1β, IL-8, TNF-α). Daphne Odora Callus Extract also promotes faster healing of epidermis cells and stimulates vascular endothelial growth factor (VEGF) expression in endothelial cells, leading to enhanced blood flow and nutrient delivery. Additionally, it boosts the production of hydrolipidic film components, which aids in reducing micro-lesions and mitigating inflammation.

Research

Clinical Evidence

High confidence
Effective range 0.002–0.01%
Optimal

N/A

Key findings

  1. 01 In a 28-day clinical study on human volunteers, a cream formulated with 0.002% Daphne Odora Callus Extract significantly accelerated skin hydration rates and provided superior protection against moisture loss compared to a placebo, specifically counteracting the negative effects of cold stress. In vitro, this concentration also inhibited inflammatory cytokines IL-1β, IL-8, and TNF-α, while increasing VEGF expression in endothelial cells.
  2. 02 In vitro, Daphne Odora Callus Extract at a 0.01% concentration markedly inhibited inflammatory cytokine expression in keratinocytes induced by bacterial infection: IL-1β by approximately 73%, IL-8 by 22%, and TNF-α by 43%. This concentration also upregulated VEGF expression by 66% in human primary endothelial cells, suggesting enhanced membrane permeability and improved nutrient delivery to skin cells.

Transparency

Dusting Analysis

Not commonly dusted

No data suggests that Daphne Odora Callus Extract is commonly used at ineffective 'dusting' percentages or that there is a red-flag concentration for lack of efficacy.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract is hydro-soluble, meaning it dissolves in water. For stability, it is prepared by homogenizing cell suspensions in a PBS buffer at pH 7.4 to produce a stable powder.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessment from the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA has been found for Daphne Odora Callus Extract in the provided research data. Sensitization risk, irritancy, and comedogenicity remain unknown.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Daphne Odora Callus Extract is a valuable ingredient, supported by clinical and in vitro data demonstrating its capacity to significantly improve skin hydration, reduce inflammation, enhance healing, and protect against environmental stressors.

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