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Moumoujus

DAPHNE KIUSIANA EXTRACT.

Insufficient Data / SKIN CONDITIONING

Daphne Kiusiana Extract is a botanical ingredient derived from the Daphne kiusiana plant, positioned for its potential in advanced skin regeneration and protection. It has been observed to significantly enhance keratinocyte migration, a fundamental process for skin repair. Beyond its regenerative actions, the extract also offers antioxidant and anti-inflammatory benefits, contributing to overall skin vitality.

Summary

Keratinocyte Migration Enhancer Antioxidant Anti-inflammatory Skin Conditioner Wound Healing Support

Science

Mechanism of Action

The primary mechanism of Daphne Kiusiana Extract involves enhancing keratinocyte migration, critical for skin repair, through the modulation of matrix metalloproteinase-9 (MMP-9) via the extracellular signal-regulated kinase (ERK) signaling pathway. Its efficacy is further supported by the presence of phenolic and flavonoid compounds, which impart antioxidant activity. Moreover, broader research on Daphne species indicates anti-inflammatory potential, with specific varieties exhibiting anti-neuroinflammatory effects via the NF-κB pathway, suggesting comprehensive cellular protective benefits.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 8.5
0 7 14

Stability

A pH range of 5.5–8.5 is suggested to prevent hydrolysis of ester and glycosidic bonds, based on studies of a related Daphne species extract, ensuring ingredient integrity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Currently, no specific CIR or SCCS safety assessment is available for Daphne Kiusiana Extract. Dermal toxicity has not been determined for this specific extract, and the broader Daphne genus is generally recognized for potential toxicity, necessitating thorough safety evaluations for topical applications before widespread use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Daphne Kiusiana Extract demonstrates promising in vitro efficacy for enhancing keratinocyte migration and offers antioxidant properties, yet comprehensive in vivo clinical studies and dermal safety assessments are required to fully ascertain its utility and safety in topical formulations.

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