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Moumoujus

DAMNACANTHUS MAJOR CALLUS EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN PROTECTING

Damnacanthus Major Callus Extract is a botanical ingredient derived from plant callus, exhibiting significant potential for advanced skincare. Research indicates its capacity to provide antioxidant protection, enhance skin hydration, and stimulate the skin's natural production of hyaluronic acid.

Summary

Antimicrobial Antioxidant Humectant Skin Protecting Hyaluronic Acid Synthesis Booster Potential Whitening

Science

Mechanism of Action

This extract confers antioxidant benefits by upregulating phospho-NFκB repressing factor in human epidermal keratinocytes and by directly scavenging free radicals (ABTS and DPPH). Its moisturizing efficacy is attributed to the upregulation of phospho-extracellular signal-regulated kinase 1/2 and cAMP response element-binding protein in artificial skin, alongside promoting hyaluronic acid synthesis in fibroblasts. Additionally, anthraquinone compounds in the plant hint at potential skin brightening effects.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.1%
Optimal

N/A

Key findings

  1. 01 Exhibited a distinct antioxidant effect on artificial skin, observed at concentrations over 600 µg/mL.
  2. 02 Showed a moisturizing effect on artificial skin, observed at concentrations over 125 µg/mL.
  3. 03 Promoted hyaluronic acid (HA) synthesis in fibroblasts, enhancing HA content to 1293 ± 142 ng/mL, at concentrations up to 100 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

No data available regarding dusting behavior for this ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for stability is not documented. Formulation considerations may include strategies for enhanced skin delivery, such as elastic nanoliposomes, as suggested for plant callus extracts.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.1%
Sensitization risk Unknown

No cytotoxicity was observed in skin fibroblasts at concentrations up to 0.01% (100 µg/mL). Furthermore, no phototoxicity was detected on artificial skin at concentrations as high as 0.1% (1 mg/mL). Official safety assessments from regulatory bodies like CIR, SCCS, or FDA are not explicitly available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Damnacanthus Major Callus Extract is a promising multi-functional ingredient demonstrating significant antioxidant, moisturizing, and hyaluronic acid boosting properties based on comprehensive in vitro and artificial skin studies, making it a valuable addition to precision skincare formulations.

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