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Moumoujus

DAMNACANTHUS MAJOR CALLUS.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Damnacanthus Major Callus is a plant-derived ingredient obtained from the undifferentiated cells of the Damnacanthus major plant. This advanced botanical extract is recognized for its significant capacity to enhance skin hydration and provide robust antioxidant protection, contributing to overall skin health and resilience.

Summary

Antioxidant Humectant Skin-Protecting Soothing

Science

Mechanism of Action

The moisturizing action of Damnacanthus Major Callus involves the upregulation of phospho-extracellular signal-regulated kinase 1/2 (ERK 1/2) and cAMP response element-binding protein (CREB) in artificial skin models. Its antioxidant efficacy is linked to the upregulation of phospho-NFκB repressing factor in human epidermal keratinocytes (HaCaT cells). Furthermore, the callus naturally contains anthraquinone compounds, such as rubiadin, which are associated with antioxidant, anti-inflammatory, and potentially skin-brightening properties.

Research

Clinical Evidence

Medium confidence
Effective range 0.0125–0.06%
Optimal

N/A

Key findings

  1. 01 Demonstrated a distinct antioxidant effect at concentrations exceeding 0.06% (600 μg/mL) in an artificial skin model.
  2. 02 Exhibited a distinct moisturizing effect at concentrations above 0.0125% (125 μg/mL) in an artificial skin model.
  3. 03 No phototoxicity was observed at concentrations up to 0.1% (1 mg/mL) using an artificial skin alternative.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No phototoxicity was detected at concentrations up to 0.1% (1 mg/mL) in an artificial skin model. This ingredient has not yet been formally reviewed by major safety assessment bodies like CIR.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Damnacanthus Major Callus is a valuable ingredient, demonstrating significant antioxidant and moisturizing capabilities with a low risk of irritation, making it suitable for a broad spectrum of precision skincare formulations.

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