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Moumoujus

DAMNACANTHUS MAJOR BRANCH/LEAF EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Damnacanthus Major Branch/Leaf Extract is a botanical ingredient demonstrating antioxidant and moisturizing properties in *in vitro* and artificial skin models. Key components within the *Damnacanthus* genus are also associated with skin brightening effects, with related species suggesting broader anti-inflammatory and antibacterial potential.

Summary

Skin Conditioning Antioxidant Moisturizing Skin Brightening Anti-inflammatory (suggested) Antibacterial (suggested)

Science

Mechanism of Action

This extract exhibits antioxidant effects by upregulating phospho-NFκB repressing factor in human epidermal keratinocytes (HaCaT cells). Its moisturizing benefits are attributed to the upregulation of phospho-extracellular signal-regulated kinase 1/2 and cAMP response element-binding protein in an artificial skin model. Anthraquinone substances found in *Damnacanthus* species contribute to its antioxidant and skin brightening actions. Broader research on related *Damnacanthus* species suggests anti-inflammatory and antibacterial properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Comprehensive toxicity data, including dermal, oral, parenteral, and inhalation, is currently 'Not determined'. There is no reported use under the FDA's Voluntary Cosmetics Reporting Program. However, an ethanol extract of *Damnacanthus major* callus demonstrated no phototoxicity up to 1 mg/mL in an artificial skin alternative.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

The ingredient shows promising *in vitro* antioxidant, moisturizing, and potential brightening effects, but comprehensive safety, formulation, and human clinical efficacy data are currently insufficient for a definitive assessment.

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