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Damnacanthus Major Adventitious Root Extract

Damnacanthus Major Adventitious Root Extract is a botanical active derived from the roots of *Damnacanthus major*, known to contain beneficial anthraquinone compounds. In artificial skin models, it has demonstrated distinct antioxidant and moisturizing effects, positioning it as a multi-functional ingredient for skin conditioning and protection.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Antimicrobial Antioxidant Humectant Skin protecting Skin conditioning

Science

Mechanism of Action

This extract supports skin health through multiple pathways. Its antioxidant capacity is mediated by the upregulation of phospho-NFκB repressing factor within human epidermal keratinocytes. For moisturizing benefits, it enhances phospho-extracellular signal-regulated kinase 1/2 and cAMP response element-binding protein in artificial skin. The presence of anthraquinone series substances, characteristic of *Damnacanthus major* roots, further contributes to its antioxidative and potential brightening properties.

Research

Clinical Evidence

Medium confidence
Effective range 0.0125–0.1%
Optimal

N/A

Key findings

  1. 01 A callus extract of *Damnacanthus major* exhibited a distinct antioxidant effect in an artificial skin alternative model.
  2. 02 The *Damnacanthus major* callus extract demonstrated a moisturizing effect in an artificial skin alternative model.
  3. 03 No phototoxicity was observed up to this concentration (1 mg/mL) when an ethanol extract of *Damnacanthus major* callus was tested in an artificial skin alternative.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding common dusting practices, typical dusting thresholds, or associated red flag percentages for this ingredient is not available in the provided data.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No official safety assessments from major regulatory bodies like CIR, SCCS, or FDA have been identified for Damnacanthus Major Adventitious Root Extract. However, *in vitro* testing using an ethanol extract of its callus indicated no phototoxic effects up to a concentration of 0.1% (1 mg/mL).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While promising in vitro antioxidant and moisturizing effects are noted, comprehensive human clinical data and full safety assessments are needed for a conclusive verdict on Damnacanthus Major Adventitious Root Extract.

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