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Moumoujus

D-NONAPEPTIDE-1.

Valuable / SKIN CONDITIONING

D-NONAPEPTIDE-1 is a precision biomimetic peptide specifically engineered to target and reverse hyperpigmentation. It actively intervenes in the melanin synthesis pathway, promoting a more uniform and luminous complexion.

Summary

Skin brightening Melanogenesis inhibitor Anti-aging Skin conditioning Smoothing Moisturizing Hyperpigmentation reduction

Science

Mechanism of Action

This synthetic peptide functions as a competitive antagonist to alpha-melanocyte-stimulating hormone (α-MSH), effectively binding to the MC1-R receptor on melanocytes. By blocking α-MSH activation, D-NONAPEPTIDE-1 disrupts the signaling cascade that leads to increased tyrosinase activity and melanin production. It systematically downregulates the expression of key enzymes like tyrosinase, TRP1, and TRP2, as well as MITF, and slows melanosome transfer, resulting in an approximate 33% reduction in overall melanin synthesis without inducing cytotoxicity or interfering with normal melanocyte function.

Research

Clinical Evidence

High confidence
Effective range ≥0.0001%
Optimal

0.0001%

Key findings

  1. 01 A facial gel containing 0.0001% pure peptide significantly reversed hyperpigmentation within 28 days, leading to a 6.42% increase in skin lightness (△L) and a 5.39% improvement in comprehensive skin state (△E) by day 56.
  2. 02 A 0.0005% concentration of the peptide in a facial gel also demonstrated significant reversal of hyperpigmentation within 28 days.
  3. 03 An estimated skin lightening effect of at least 33% was observed, with continued improvement over time. A prospective double-blinded, randomized controlled pilot study lasting eight months showed observable amelioration in melasma severity scores and mean melanin index.

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not indicate D-NONAPEPTIDE-1 is commonly used below its clinically effective concentrations or that it is subject to 'dusting'.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Optimal stability and efficacy are maintained within a pH range of 5.0 to 7.0. For potency retention, D-NONAPEPTIDE-1 should be stored in a cool, ventilated environment: 2°C to 8°C for short-term and -20°C ± 5°C for long-term storage, protected from direct sunlight, heat, and moisture.

Conflicts

  • Formaldehyde-releasing preservatives
  • Paraben
  • Benzotriazolyl Dodecyl P-Cresol

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

D-NONAPEPTIDE-1 is generally considered safe for topical cosmetic application, presenting a low risk of irritation or adverse reactions. Clinical studies confirm its excellent tolerability across most skin types, including sensitive skin, and it does not demonstrate obvious risks regarding carcinogenicity, developmental/reproductive toxicity, or allergies/immunotoxicity. While not listed in EU Annex II (prohibited) or Annex III (restricted), it is included in the Inventory of Existing Cosmetic Ingredients in China (IECIC). Patch testing is advised for individuals with known sensitivities.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

D-NONAPEPTIDE-1 is a valuable ingredient for targeted skincare, offering clinically proven efficacy in reversing hyperpigmentation and promoting skin brightening, coupled with a strong safety profile and broad skin compatibility.

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