Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

D-HEPTAPEPTIDE-1.

Valuable / SKIN CONDITIONING

D-HEPTAPEPTIDE-1 is a precision-engineered synthetic peptide designed to activate the skin's inherent self-protective mechanisms. It demonstrably reduces UV-induced DNA damage and enhances the skin's overall antioxidant capacity, safeguarding against environmental stressors.

Summary

Antioxidant DNA protection Anti-aging Skin conditioning Environmental protection

Science

Mechanism of Action

This modified synthetic recombinant peptide, also known as Acetyl sh-Heptapeptide-1 or PerfectionPeptide P7, operates by engaging the Nrf2 (Nuclear factor erythroid 2-related factor 2) pathway. It specifically binds to Keap1 (Kelch-like ECH-associated protein 1), preventing the formation of the Nrf2/Keap1 complex and subsequently activating Nrf2. Activated Nrf2 acts as a master switch, inducing the production of cell-protective enzymes, accelerating the breakdown of free radicals and toxins, and aiding in the replenishment of cellular antioxidants like glutathione. This mechanism effectively protects skin cells, including Langerhans cells, from UV- and oxidative stress-induced DNA damage, thereby enhancing the skin's resilience against extrinsic and chronological aging.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.014%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

Peptides generally exhibit optimal solubility and stability within a near-neutral pH range of 6.0 to 8.0, where they carry more charges. D-HEPTAPEPTIDE-1 is susceptible to degradation by high temperatures, direct sunlight, and certain oxidative excipients such as peroxides. Utilizing advanced delivery systems like Solid Lipid Nanoparticles (SLN) or other emulsion strategies is crucial for enhancing its skin penetration, protecting its delicate structure, and facilitating controlled release, especially given its hydrophilic nature and molecular size.

Conflicts

  • High temperatures
  • Direct sunlight
  • Excipients containing oxidative reactants (e.g., peroxides)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety assessments for Acetyl sh-Heptapeptide-1 (D-HEPTAPEPTIDE-1) by regulatory bodies such as CIR (Cosmetic Ingredient Review), SCCS (Scientific Committee on Consumer Safety), or FDA were not identified in the publicly available information. While CIR has reviewed the general class of peptides, this specific heptapeptide is not explicitly covered.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

D-HEPTAPEPTIDE-1 is a valuable peptide, demonstrating a clear mechanism of action in activating the Nrf2 pathway and clinically proven efficacy in reducing UV-induced DNA damage, making it a powerful ingredient for environmental protection and anti-aging formulations.

Related

Similar Ingredients

Finding similar ingredients…