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D-ARGINYL TYROSINYL ORNITHINYL PHENYLALANINE.

Valuable / SKIN CONDITIONING - MISCELLANEOUS

D-Arginyl Tyrosinyl Ornithinyl Phenylalanine is a synthetic tetrapeptide (RYXF) engineered as a sophisticated guiding molecule within advanced skincare delivery systems. It precisely targets and facilitates the controlled release of encapsulated active ingredients directly to skin cell mitochondria, significantly amplifying their efficacy. This versatile ingredient also functions as a skin conditioning agent, improving overall skin appearance and texture.

Summary

Skin conditioning Targeted active ingredient delivery Mitochondrial targeting Enhanced penetration Sustained release

Science

Mechanism of Action

This synthetic tetrapeptide, designated RYXF, operates as a specialized "guiding peptide" within an advanced delivery system, commercially known as Trojan®. Its primary function is to direct encapsulated active ingredients precisely to skin cell organelles, notably mitochondria. This targeted delivery optimizes the efficacy of active ingredients, allowing for their use at lower concentrations, and ensures a sustained, controlled release within the target cells. Beyond its delivery role, the peptide actively conditions the skin, diminishing flaking and restoring suppleness to improve the appearance of dry or compromised skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The peptide is described as covalently bonded within a polymeric capsule, typically derived from Lactic Acid/Glycolic Acid Copolymer (PLGA), as part of its advanced delivery system. While specific pH stability data for this exact peptide is not provided, peptides generally exhibit pH-dependent solubility and stability, with optimal conditions varying by structure (e.g., some show higher solubility at pH 5-6 and increased thermal stability around pH 7.0).

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Low

There is no direct assessment by the CIR, SCCS, or FDA specifically for D-Arginyl Tyrosinyl Ornithinyl Phenylalanine. However, general safety assessments for α-amino acids, which are the fundamental components of peptides, conclude them as safe for cosmetic use at typical concentrations. The CIR Expert Panel posits that amino acid concentrations in cosmetics are generally low, minimizing risks of significant dermal absorption or incidental ingestion that could lead to systemic effects. A component amino acid, Phenylalanine, is considered potentially safe for short-term topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This tetrapeptide is a valuable component for advanced skincare formulations, optimizing the delivery and efficacy of active ingredients to cellular targets while also providing direct skin conditioning benefits.

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