Science
Mechanism of Action
This extract is abundant in bioactive compounds including polyphenols (flavones, isoflavones, flavonols, hydroxycinnamic acid derivatives, quercetin hexoside, rutin), carotenoids (like β-carotene), and anthocyanins. Its primary mechanism on the skin involves potent antioxidant activity, where it neutralizes lipid-derived free radicals and prevents hydroperoxides from generating new radicals, thereby mitigating cellular damage. Concurrently, it exerts anti-inflammatory effects by significantly reducing key inflammatory mediators such as PGE-2, IL-1β, and TNF-α, and by inhibiting enzymes like lipoxygenase (LOX).
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Exerted anti-inflammatory activity by reducing inflammatory markers (PGE-2, IL-1β, and TNF-α) in LPS-induced macrophages (RAW 264.7 cell line).
- 02 Demonstrated antioxidant capacity (ABTS method).
- 03 Showed anti-inflammatory activity by inhibiting the LOX enzyme.
- 04 Exhibited antioxidant activity (DPPH method).
- 05 Demonstrated no cytotoxicity in HK-2, THP-1 monocytes, and SH-5YSY neuroblastoma cell lines.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Stock solutions were stored in the dark at 4°C, indicating potential sensitivity to light and temperature fluctuations.
Safety
Safety Profile
No specific CIR, SCCS, or FDA safety status has been established. In vitro studies indicated no cytotoxicity up to 120 μg/ml extract across various cell lines.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cyphomandra Betacea Fruit Extract is a valuable ingredient, offering potent antioxidant and anti-inflammatory properties supported by robust in vitro data, making it suitable for a wide range of skin types and formulations.
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References
Sources