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Moumoujus

CYNARA SCOLYMUS LEAF EXTRACT.

Valuable CAS 84012-14-6 / SKIN CONDITIONING

Cynara Scolymus Leaf Extract is a potent botanical powerhouse derived from artichoke leaves, celebrated for its multifaceted benefits in skin rejuvenation. Rich in polyphenols and antioxidants, it actively combats oxidative stress and inflammation, while promoting cellular renewal and barrier integrity. Clinically shown to improve skin elasticity, reduce roughness, and minimize the appearance of wrinkles, it contributes to a more youthful and radiant complexion.

Summary

Antioxidant Anti-aging Anti-inflammatory Skin conditioning Sebum regulating Pore tightening Detoxifying Barrier strengthening Smoothing Moisturizing

Science

Mechanism of Action

This extract works through several pathways to enhance skin health. Its high antioxidant content, including polyphenols and Vitamin C, neutralizes free radicals, mitigating oxidative stress and offering protection against environmental aggressors and UV-induced damage. Key compounds like cynaropicrin specifically suppress photoaging by inhibiting NF-κB-mediated transactivation and reducing reactive oxygen species (ROS) and inflammatory cytokines. Furthermore, its anti-inflammatory properties soothe irritation and redness, while its ability to regulate sebum and act as an astringent refines pore appearance. The extract also supports skin detoxification, strengthens the skin's barrier function by reinforcing tight junction complexes, and improves microcirculation, collectively promoting cellular renewal and enhanced skin firmness and elasticity.

Research

Clinical Evidence

High confidence
Effective range ≥0.002%
Optimal

0.002%

Key findings

  1. 01 A cream containing a 0.002% Artichoke Polyphenol Extract (comprised of 87% specific chlorogenic and dicaffeoylquinic acids) demonstrated significant improvements in skin parameters. In female volunteers aged 35-55 with sagging facial skin, a 28-day application resulted in a 19.74% improvement in skin roughness and an 11.45% increase in elasticity compared to a placebo.
  2. 02 A cosmetic product featuring Cynara Scolymus Leaf Extract as an active ingredient yielded notable anti-aging effects over a 28-day period. Participants experienced a 5.2% decrease in skin wrinkles, a 7.0% reduction in skin roughness, and a 19.0% boost in skin radiance. The product also increased total antioxidant capacity by 20.2% and decreased inflammatory TNF-α levels by 8.2%, leading to an average reduction in calculated biological skin age by 2.3 ± 0.5 years.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Cynara Scolymus Leaf Extract is generally considered safe for topical application, with reported side effects being rare. Mild skin irritations, such as redness or itching, may occur in individuals with highly sensitive skin or known allergies to artichokes; patch testing is recommended for these cases. While the European Cosmetics Regulation permits its use, the Cosmetic Ingredient Review (CIR) has not yet specifically assessed its safety for cosmetic applications. The FDA lists 'Artichoke Leaves' as 'Generally Recognized As Safe' (GRAS) for food use, but this designation does not equate to a specific topical cosmetic safety assessment. Independent evaluations, such as EWG Skin Deep, rate it with a low concern for cancer, allergies & immunotoxicity, and developmental and reproductive toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Cynara Scolymus Leaf Extract is a valuable multi-functional ingredient that significantly addresses signs of aging, improves skin texture, and enhances radiance, while offering broad skin compatibility and a low risk profile.

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