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Moumoujus

CYNANCHUM WILFORDII ROOT EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Cynanchum Wilfordii Root Extract is a botanical active revered for its conditioning properties. It delivers targeted anti-inflammatory benefits by modulating cellular adhesion, complemented by antioxidant capabilities that shield skin from environmental damage.

Summary

Skin Conditioning Anti-inflammatory Antioxidant

Science

Mechanism of Action

This extract primarily functions as a skin conditioning agent. Its anti-inflammatory action is precisely achieved by suppressing the expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1) in TNF-α-stimulated cells, a process operating through the NF-κB pathway. Additionally, it provides antioxidant protection, effectively neutralizing free radicals to prevent oxidative damage.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Cynanchum Wilfordii Root Extract is commonly used as a 'dusting' ingredient at ineffective percentages in cosmetic formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The optimal pH range for stability in cosmetic formulations is currently unknown. The extract's components exhibit varied polarities, allowing for preparation using a range of solvents including water, ethanol (with 90% ethanol noted for optimal inhibition of VCAM-1 expression in some contexts), ethyl acetate, dichloromethane, petroleum ether, and n-butanol.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Cynanchum Wilfordii Root Extract has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel or the Scientific Committee on Consumer Safety (SCCS). However, it holds registration as a non-toxic food material by the Ministry of Food and Drug Safety (MFDS) in Korea, supported by centuries of traditional use. Acute and 13-week subchronic oral toxicity studies in rats showed no observed adverse-effect level greater than 2000 mg/kg/day. Additionally, studies on a standardized blend containing this extract indicated no estrogenic activity at tested concentrations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cynanchum Wilfordii Root Extract is a valuable ingredient, offering proven in vitro anti-inflammatory and antioxidant benefits, suitable for all skin types, with a strong traditional safety record, though further topical clinical data would be beneficial.

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