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CYCLOPIA SUBTERNATA FLOWER/LEAF/STEM EXTRACT.

Valuable CAS - / ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING

Cyclopia Subternata Flower/Leaf/Stem Extract, derived from the Honeybush plant, is a potent botanical ingredient abundant in phenolic compounds. It exhibits robust antioxidant, anti-inflammatory, and cellular energy-boosting capabilities, making it effective in protecting the skin from environmental stressors. This extract supports overall skin health by enhancing vital cellular functions and reducing visible signs of oxidative damage.

Summary

Antioxidant Anti-inflammatory Antimicrobial Anti-allergic Mitochondrial support Skin conditioning

Science

Mechanism of Action

This extract is rich in various phenolic compounds, including flavanones, xanthones (such as mangiferin and hesperidin), flavones, and epigallocatechin gallate. These constituents provide significant antioxidant activity by scavenging free radicals and inhibiting lipid peroxidation. Furthermore, it demonstrates anti-inflammatory, antimicrobial, and anti-allergic effects, partly by inhibiting mast cell degranulation. At a fundamental cellular level, Cyclopia Subternata has been shown to increase ATP production, optimize cellular respiration, and maintain mitochondrial membrane potential, collectively rescuing bioenergetic deficits and enhancing skin's resilience against oxidative stress and environmental damage.

Research

Clinical Evidence

Medium confidence
Effective range 1e-7–2.5%
Optimal

N/A

Key findings

  1. 01 In vitro studies on human neuroblastoma cells demonstrated that the aqueous extract of Cyclopia Subternata increased ATP production, cellular respiration, and mitochondrial membrane potential (MMP), concurrently protecting against oxidative stress.
  2. 02 Semi-solid formulations containing related honeybush extracts (Cyclopia maculata and Cyclopia genistoides) exhibited notable antioxidant activity.
  3. 03 Topical application of semi-solid formulations with related honeybush extracts (Cyclopia maculata and Cyclopia genistoides) resulted in improved skin smoothness.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that this ingredient is commonly 'dusted' or to establish specific dusting thresholds.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Formulations containing analogous honeybush extracts (Cyclopia maculata and Cyclopia genistoides) showed signs of instability over a 3-month accelerated stability period. Variations in pH were observed, indicating a potential sensitivity of key active compounds, such as mangiferin and hesperidin, to significant pH fluctuations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA have been found for Cyclopia Subternata Flower/Leaf/Stem Extract. A related extract, 'cyclopia genistoides flower/leaf/stem extract', has no reported GHS hazard statements. Its extensive traditional use as a tea suggests a history of general safety, though specific dermatological safety data remains limited.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cyclopia Subternata Flower/Leaf/Stem Extract is a valuable ingredient, demonstrating significant antioxidant, anti-inflammatory, and mitochondrial-boosting benefits for various skin types, although formal safety reviews are pending and formulation stability warrants consideration.

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