Science
Mechanism of Action
This extract functions as a robust antioxidant by actively inhibiting reactive oxygen species (ROS) production and scavenging free radicals, thereby protecting skin from oxidative stress. Its anti-aging properties are further evidenced by its ability to suppress collagen degradation, downregulate matrix metalloproteinase (MMP) activity, and inhibit key enzymes such as collagenase (IC50 of 42.5 ± 1.05 μg/mL in vitro), tyrosinase (IC50 of 67.42 ± 1.45 µg/mL in vitro), and hyaluronidase (IC50 range of 10.99 ± 1.56 to 14.62 ± 0.21 µg/mL in vitro). The extract also exhibits anti-inflammatory effects by reducing skin inflammation and inhibiting UVB-induced activation of MAPK signaling in human keratinocytes, contributing to overall skin health and resilience.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Significantly improved global skin wrinkle grade, skin elasticity, and skin hydration. Also, significantly decreased transepidermal water loss (TEWL) in human subjects with crow's feet wrinkles.
Transparency
Dusting Analysis
No data available to suggest this ingredient is commonly dusted or to establish a dusting threshold.
The Formula
Formulation
Stability
Related honeybush extracts (Cyclopia maculata and Cyclopia genistoides) in semi-solid formulations demonstrated instability over 3 months, with pH changes up to 20-31% when stored at 40°C/75%RH. This suggests active components like mangiferin and hesperidin may be pH-sensitive. No specific optimal pH range for Cyclopia intermedia leaf extract has been identified.
Safety
Safety Profile
Oral supplementation of fermented Cyclopia intermedia extract (HU-018) at 400 mg/day and 800 mg/day for 12 weeks showed no reported adverse effects in human clinical trials. EWG Skin Deep rates Cyclopia Intermedia Leaf Extract with 'LOW' concerns across categories including Cancer, Allergies & Immunotoxicity, and Developmental and Reproductive Toxicity, although data availability is listed as 'None' to 'Limited-Fair'. No specific regulatory status or maximum concentration for topical use has been established by CIR, SCCS, or FDA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable ingredient for anti-aging and hydrating formulations, exhibiting significant antioxidant, anti-inflammatory, and enzyme-inhibiting activities, though further topical clinical data would solidify its optimal application parameters.
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References
Sources