Science
Mechanism of Action
This extract exerts its benefits through a rich array of phenolic compounds, including Mangiferin, Hesperidin, Hesperetin, and Isosakuranetin. These active constituents provide robust antioxidant protection, mitigating cellular damage from free radicals, alongside anti-inflammatory and antimicrobial actions. Furthermore, it supports a healthier lipid barrier, helps to suppress collagen degradation, and rescues mitochondrial function from oxidative injury, all contributing to enhanced skin resilience and a reduction in visible wrinkles.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 At a 2% concentration, formulations significantly enhanced skin surface smoothness and exhibited notable antioxidant activity. However, skin penetration of these formulations was not found to be substantial.
- 02 In vitro, concentrations exceeding 0.6250 mg/ml demonstrated potent antioxidant effects by decreasing malondialdehyde (MDA) formation, thereby reducing lipid peroxidation and enhancing hydroxyl radical scavenging abilities.
Transparency
Dusting Analysis
Clinical data indicates that formulations containing 2% Cyclopia Genistoides Leaf Extract effectively improve skin smoothness and provide antioxidant benefits. Therefore, product concentrations at or above 2% are expected to be functionally active, suggesting that lower, non-functional percentages are not a common industry practice for this ingredient.
The Formula
Formulation
Stability
Formulations incorporating 2% Cyclopia Genistoides Leaf Extract demonstrated stability challenges during accelerated studies (3 months at 40°C/75%RH), with pH fluctuations reaching up to 31%. This instability may be attributed to the degradation of key phenolic compounds such as mangiferin and hesperidin. Furthermore, the average particle size of 14.09 µm for C. genistoides formulations may impede optimal skin penetration.
Safety
Safety Profile
No specific safety assessments from regulatory bodies like CIR, SCCS, or FDA were found, and its CIR status is listed as 'insufficient data.' Despite this, a supplier claims the ingredient is 'Non-irritant' and 'safe,' and GHS classification reports no hazards, although specific oral, dermal, and inhalation toxicity levels were 'Not determined.'
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cyclopia Genistoides Leaf Extract is a valuable botanical offering significant antioxidant, anti-inflammatory, and anti-aging benefits, making it particularly effective for improving skin smoothness and barrier function, though its formulation stability and penetration require careful consideration.
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References
Sources