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CYCLOPENTADECANONE.

Optional CAS 502-72-7 / DEODORANT, FRAGRANCE

Cyclopentadecanone is a synthetic macrocyclic ketone primarily valued in cosmetic formulations for its distinct, long-lasting musky and sweet fragrance. It functions effectively as a fixative, extending the longevity of scent profiles in various products.

fragrance ingredient fixative

Science

This compound's primary role is olfactory, imparting a musky-sweet aroma and acting as a fragrance fixative. The available research does not indicate a specific biological or therapeutic mechanism of action on the skin itself.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

Cyclopentadecanone is a fragrance ingredient, not an active compound typically associated with 'dusting' or claims of standalone efficacy for skin treatment.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Cyclopentadecanone is insoluble in water but exhibits good solubility in various organic solvents such as ethanol, acetone, chloroform, and diethyl ether, making it suitable for incorporation into oil-based or emulsified cosmetic formulations. While no specific optimal pH range for its stability has been identified, general skincare product stability is often maintained within a pH of 4.5-6.5.


Safety

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

A comprehensive dermatologic and toxicologic review supports Cyclopentadecanone's safety as a fragrance ingredient. Human patch testing at a 10% solution demonstrated no irritation or sensitization. The maximum recommended concentration in fragrance concentrates is 1.0000%, with calculated maximum dermal exposures for its chemical group ranging from 0.13% to 1.10%. While PubChem reports it generally does not meet GHS hazard criteria, EWG notes a moderate concern for 'Allergies & Immunotoxicity'. It is an FDA-listed and EPA-active substance, confirming its allowed use.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

Cyclopentadecanone is a well-tolerated, long-lasting musky fragrance and fixative, suitable for formulations where scent enhancement is desired, but it offers no direct therapeutic skin benefits.


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