Science
Mechanism of Action
This extract functions primarily as a humectant, drawing and retaining moisture to improve skin hydration and support barrier integrity. Its rich phytochemical profile, including phenolic compounds, flavonoids, and triterpenoids, confers robust antioxidant activity, protecting skin from oxidative stress, while also demonstrating antimicrobial and soothing anti-inflammatory effects.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No specific data regarding cosmetic dusting or red-flag percentages for topical application were available in the provided research.
The Formula
Formulation
Stability
The phenolic compounds within the extract are susceptible to degradation, with stability potentially compromised by factors such as pH fluctuations, elevated temperatures, oxygen exposure, and light.
Conflicts
- Concentrations exceeding approximately 0.18% to 0.24% have been noted to impart a natural yellow-brown coloration to final products, which may affect the desired aesthetic in cosmetic formulations.
Safety
Safety Profile
Although not yet reviewed by the Cosmetic Ingredient Review (CIR), the United States FDA approved Cyclocarya paliurus leaves as a dietary supplement in 1999. Oral toxicity studies in rats established a non-observed-adverse-effect level (NOAEL) of 5,000 mg/kg body weight/day and a maximum tolerated dose (MTD) exceeding 10,000 mg/kg body weight. Genotoxicity and teratogenicity assays at very high oral dosages (up to 40.0 g/kg·bw, 300-fold human daily intake equivalent) found the extract to be non-mutagenic and non-teratogenic. While these studies pertain to oral intake, they collectively indicate a generally low toxicity profile; however, specific topical sensitization data remains unknown.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cyclocarya Paliurus Leaf Extract offers promising hydrating, antioxidant, and anti-inflammatory benefits, but comprehensive topical clinical efficacy data and full topical safety reviews are currently limited.
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References
Sources